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Genomic profiling of messenger RNAs and microRNAs in muscle cells treated in vitro with TNF-alpha and IFN-gamma

Abstract

The skeletal muscle atrophy is a common phenomenon in many chronic systemic diseases such a sepsis, chronic heart failure, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, AIDS and cancer. These diseases may be accompanied by a complex metabolic syndrome characterized by muscle wasting, denominated cachexia. The molecular pathways responsible for cachexia are not completely understood, however, evidence suggest that pro-inflammatory cytokines like Tumor Necrosis Factor (TNF)-± and Interferon (INF)-³ have a key role in molecular pathways related to loss of function and muscle mass. The complexity of mechanisms controlling gene expression in this process suggests the involvement of additional regulatory molecules, such as microRNAs; these RNA molecules encoded by the genome regulate the function of skeletal muscle during development and various muscle diseases. MicroRNAs orchestrate common pathways or biological function, this unique feature gives rise as an effective tool for determining the pathways involved in specific diseases or biological processes. The hypothesis of this work is that the muscle atrophy induced by TNF-± and INF-³ has a microRNAs and mRNAs expression profile that will allow the identification of regulatory networks and molecular pathways that coordinates the degradation of muscle proteins. (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERNANDEZ, GEYSSON JAVIER; FERREIRA, JUAREZ HENRIQUE; VECHETTI JR, IVAN JOSE; DE MORAES, LEONARDO NAZARIO; CURY, SARAH SANTILONI; FREIRE, PAULA PACCIELLI; GUTIERREZ, JAYSON; FERRETTI, RENATO; DAL-PAI-SILVA, MAELI; ROGATTO, SILVIA REGINA; et al. MicroRNA-mRNA Co-sequencing Identifies Transcriptional and Post-transcriptional Regulatory Networks Underlying Muscle Wasting in Cancer Cachexia. FRONTIERS IN GENETICS, v. 11, . (13/02005-0, 12/13961-6, 13/50343-1, 16/08294-1, 14/13941-0, 11/16282-0)
PACCIELLI FREIRE, PAULA; JAVIER FERNANDEZ, GEYSSON; DE MORAES, DIOGO; SANTILONI CURY, SARAH; DAL PAI-SILVA, MAELI; DOS REIS, PATRICIA PINTOR; ROGATTO, SILVIA REGINA; CARVALHO, ROBSON FRANCISCO. The expression landscape of cachexia-inducing factors in human cancers. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, . (13/50343-1, 18/19695-2, 12/13961-6, 14/13941-0)
FREIRE, PAULA PACCIELLI; FERNANDEZ, GEYSSON JAVIER; CURY, SARAH SANTILONI; DE MORAES, DIOGO; OLIVEIRA, JAKELINE SANTOS; DE OLIVEIRA, GRASIELI; DAL-PAI-SILVA, MAELI; DOS REIS, PATRICIA PINTOR; CARVALHO, ROBSON FRANCISCO. The Pathway to Cancer Cachexia: MicroRNA-Regulated Networks in Muscle Wasting Based on Integrative Meta-Analysis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 8, . (14/13783-6, 12/13961-6)
FREIRE, PAULA PACCIELLI; CURY, SARAH SANTILONI; DE OLIVEIRA, GRASIELI; FERNANDEZ, GEYSSON JAVIER; MORAES, LEONARDO NAZARIO; DA SILVA DURAN, BRUNO OLIVEIRA; FERREIRA, JUAREZ HENRIQUE; FUZIWARA, CESAR SEIGI; KIMURA, EDNA TERUKO; DAL-PAI-SILVA, MAELI; et al. Osteoglycin inhibition by microRNA miR-155 impairs myogenesis. PLoS One, v. 12, n. 11, . (14/13783-6, 12/13961-6)
GARCIA, SOFIA; NISSANKA, NADEE; MARECO, EDSON A.; ROSSI, SUSANA; PERALTA, SUSANA; DIAZ, FRANCISCA; ROTUNDO, RICHARD L.; CARVALHO, ROBSON F.; MORAES, CARLOS T.. Overexpression of PGC-1 alpha in aging muscle enhances a subset of young-like molecular patterns. AGING CELL, v. 17, n. 2, . (12/13961-6)
CURY, SARAH SANTILONI; FREIRE, PAULA PACCIELLI; MARTINUCCI, BRUNO; DOS SANTOS, VERIDIANA CARVALHO; DE OLIVEIRA, GRASIELI; FERRETTI, RENATO; DAL-PAI-SILVA, MAELI; PACAGNELLI, FRANCIS LOPES; DELELLA, FLAVIA KARINA; CARVALHO, ROBSON FRANCISCO. Fractal dimension analysis reveals skeletal muscle disorganization in mdx mice. Biochemical and Biophysical Research Communications, v. 503, n. 1, p. 109-115, . (12/13961-6)
DE OLIVEIRA, GRASIELI; FREIRE, PAULA PACCIELLI; MIEKO OMOTO, ANA CAROLINA; CURY, SARAH SANTILONI; FUZIWARA, CESAR SEIGI; KIMURA, EDNA TERUKO; DAL-PAI-SILVA, MAELI; CARVALHO, ROBSON FRANCISCO. Osteoglycin post-transcriptional regulation by miR-155 induces cellular architecture changes in H9c2 cardiomyoblasts. Gene, v. 676, p. 9-15, . (14/14340-0, 12/13961-6)
FERREIRA, JUAREZ H.; CURY, SARAH S.; VECHETTI-JUNIOR, IVAN J.; FERNANDEZ, GEYSSON J.; MORAES, LEONARDO N.; ALVES, CARLOS A. B.; FREIRE, PAULA P.; FREITAS, CARLOS E. A.; DAL-PAI-SILVA, MAELI; CARVALHO, ROBSON F.. Low-level laser irradiation induces a transcriptional myotube-like profile in C2C12 myoblasts. Lasers in Medical Science, v. 33, n. 8, p. 1673-1683, . (12/13961-6)

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