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Genomic profiling of messenger RNAs and microRNAs in cancer cachexia

Grant number: 13/50343-1
Support Opportunities:Regular Research Grants
Duration: October 01, 2013 - September 30, 2014
Field of knowledge:Biological Sciences - Morphology
Convênio/Acordo: Ohio State University
Principal Investigator:Robson Francisco Carvalho
Grantee:Robson Francisco Carvalho
Principal researcher abroad: Denis Christian Guttridge
Institution abroad: Ohio State University, Columbus, United States
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated research grant:12/13961-6 - Genomic profiling of messenger RNAs and microRNAs in muscle cells treated in vitro with TNF-alpha and IFN-gamma, AP.R

Abstract

The Brazil-USA collaboration provides an exciting opportunity to explore different molecular, cellular, and physiological aspects of muscle wasting. OSU has expertise in cancer cachexia, especially dissecting the mechanisms by which NF-kB regulates muscle differentiation using different in vitro and in vivo experimental models for functional studies, which can complement the UNESP expertise in cardiac cachexia, microRNAs, transcriptomics, and bioinformatics analyses which together, will allow us to ultimately impact on cancer cachexia. The objective of this Brazil-USA research collaboration is to improve cancer cachexia research in both countries. This will be achieved by effective knowledge exchange and research collaboration between the groups from both countries. Additional short-term metrics of success will include collaborative research grants, training awards, and publication of co-authored papers. The long-term goal is to not only to better dissect the function and mechanisms by which genes regulates muscle wasting in cancer cachexia, but to also translate this information to identify new drug targets to support the development of new therapeutic strategies. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PACCIELLI FREIRE, PAULA; JAVIER FERNANDEZ, GEYSSON; DE MORAES, DIOGO; SANTILONI CURY, SARAH; DAL PAI-SILVA, MAELI; DOS REIS, PATRICIA PINTOR; ROGATTO, SILVIA REGINA; CARVALHO, ROBSON FRANCISCO. The expression landscape of cachexia-inducing factors in human cancers. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, v. 11, n. 4, p. 15-pg., . (14/13941-0, 12/13961-6, 18/19695-2, 13/50343-1)
FERNANDEZ, GEYSSON JAVIER; FERREIRA, JUAREZ HENRIQUE; VECHETTI JR, IVAN JOSE; DE MORAES, LEONARDO NAZARIO; CURY, SARAH SANTILONI; FREIRE, PAULA PACCIELLI; GUTIERREZ, JAYSON; FERRETTI, RENATO; DAL-PAI-SILVA, MAELI; ROGATTO, SILVIA REGINA; et al. MicroRNA-mRNA Co-sequencing Identifies Transcriptional and Post-transcriptional Regulatory Networks Underlying Muscle Wasting in Cancer Cachexia. FRONTIERS IN GENETICS, v. 11, . (13/02005-0, 12/13961-6, 13/50343-1, 16/08294-1, 14/13941-0, 11/16282-0)
FREIRE, PAULA P.; MARQUES, ALEXANDRE H. C.; BAIOCCHI, GABRIELA C.; SCHIMKE, LENA F.; FONSECA, DENNYSON L. M.; SALGADO, RANIERI C.; FILGUEIRAS, IGOR S.; NAPOLEAO, SARAH M. S.; PLACA, DESIREE R.; AKASHI, KAREN T.; et al. The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2-infected patients by sex and age. JCI INSIGHT, v. 6, n. 10, . (20/09146-1, 20/01688-0, 17/05264-7, 13/50343-1, 20/07069-0, 20/07972-1)
PACCIELLI FREIRE, PAULA; JAVIER FERNANDEZ, GEYSSON; DE MORAES, DIOGO; SANTILONI CURY, SARAH; DAL PAI-SILVA, MAELI; DOS REIS, PATRICIA PINTOR; ROGATTO, SILVIA REGINA; CARVALHO, ROBSON FRANCISCO. The expression landscape of cachexia-inducing factors in human cancers. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, . (13/50343-1, 18/19695-2, 12/13961-6, 14/13941-0)
CURY, S. S.; OLIVEIRA, J. S.; BIAGI-JUNIOR, C. A. O.; SILVA JR, W. A.; REIS, P. P.; CABRAL-MARQUES, O.; HASIMOTO, E. N.; FREIRE, P. P.; CARVALHO, R. F.. Transcriptional profiles and common genes link lung cancer with the development and severity of COVID-19. Gene, v. 852, p. 11-pg., . (13/50343-1, 20/09146-1)
FREIRE, PAULA PACCIELLI; FERNANDEZ, GEYSSON JAVIER; DE MORAES, DIOGO; CURY, SARAH SANTILONI; DAL PAI-SILVA, MAELI; DOS REIS, PATRICIA PINTOR; ROGATTO, SILVIA REGINA; CARVALHO, ROBSON FRANCISCO. The authors reply: Comment on "The expression landscape of cachexia-inducing factors in human cancers" by Freire et al.. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, v. 11, n. 6, p. 4-pg., . (12/13961-6, 18/19695-2, 14/13941-0, 13/50343-1)

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