Development of platform with mucoadhesive systems for drug release on the buccal cavity

• Grant number: 12/07251-6
• Support Opportunities: Regular Research Grants
• Duration: December 01, 2012 - November 30, 2014
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Osvaldo de Freitas
• Grantee: Osvaldo de Freitas
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated researchers: Cristiane Masetto de Gaitani ; Renata Fonseca Vianna Lopez ; Vinícius Pedrazzi

Abstract

This proposal aims to develop a platform of mucoadhesive systems for topical/local release of drugs in the oral cavity. The study has as its starting point the use of anesthetic drugs in order to replace the injectable anesthetic in dental procedures. It will be developed and compared: i.fast-dissolving tablets, ii. films and iii. semi-solid mucoadhesive systems. The formulations will be characterized physical and physicochemically, and in vitro and ex vivo tests will be performed to assess whether the formulations present suitable properties. Moreover, we will investigate the potential of the application of iontophoresis to modulate the release rate, permeation and to maintain the effect of the drugs from the films and semi-solid formulations. In all cases, statistical tools will be used to the experimental design and selection of formulations with improved characteristics. It is expected that at the set time, the development of this research project contemplates: knowledge generation (undergraduate research work,master dissertation and doctoral thesis) scientific papers published in national and international journals; presentation in scientific meetings; technological advancement through the filing of a patent application; formation of highly qualified human resources in the Pharmaceutical science; strengthening and consolidation of research team in a strategic area for the country. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA FAVACHO, HUGO ALEXANDRE; DO COUTO, RENE OLIVEIRA; FERREIRA DUARTE, MAIRA PERES; GAROFO PEIXOTO, MARIA PAULA; VIANNA LOPEZ, RENATA FONSECA; PEDRAZZI, VINICIUS; DE GAITANI, CRISTIANE MASETTO; DE FREITAS, OSVALDO. Synergy between surfactants and mucoadhesive polymers enhances the transbuccal permeation of local anesthetics from freeze-dried tablets. Materials Science & Engineering C-Materials for Biological Applications, v. 108, MAR 2020. (12/05644-0, 12/06167-1, 12/07251-6, 13/12174-3, 14/22451-7)

DO COUTO, RENE OLIVEIRA; CUBAYACHI, CAMILA; CALEFI, PAULO LINARES; VIANNA LOPEZ, RENATA FONSECA; PEDRAZZI, VINICIUS; DE GAITANI, CRISTIANE MASETTO; DE FREITAS, OSVALDO. Combining amino amide salts in mucoadhesive films enhances needle-free buccal anesthesia in adults. JOURNAL OF CONTROLLED RELEASE, v. 266, p. 205-215, NOV 28 2017. (12/07251-6, 12/05644-0, 13/12174-3, 14/22451-7, 12/06167-1)

DO COUTO, RENO O.; SOMMERFELD, SVEN D.; DUBE, KOUSTUBH; DE FREITAS, OSVALDO; KOHN, JOACHIM. PRELIMINARILY DEVELOPMENT OF A MOISTURE-ACTIVATED BIORESORBABLE POLYMERIC PLATFORM FOR DRUG DELIVERY. Química Nova, v. 38, n. 7, p. 902-909, AUG 2015. (12/06167-1, 12/07251-6, 13/12174-3)

COUTO, RENE O.; CUBAYACHI, CAMILA; LOPEZ, RENATA F. V.; DE GAITANI, CRISTIANE M.; PEDRAZZI, VINICIUS; DE FREITAS, OSVALDO. A simple and high-resolution HPLC-PDA method for simultaneous quantification of local anesthetics in in vitro buccal permeation enhancement studies. BIOMEDICAL CHROMATOGRAPHY, v. 30, n. 6, p. 857-866, JUN 2016. (12/06167-1, 12/07251-6, 12/05644-0)

BASTOS, MONICA DANIELLE RIBEIRO; DE FIGUEIREDO, FELLIPE AUGUSTO TOCCHINI; MACEDO, ANA PAULA; SILVA, AMANDA CRISTINA FUNARI; FERREIRA, MAIRA PERES; DE FREITAS, OSVALDO; PEDRAZZI, VINICIUS. Local anesthetic improves individuals affected with herpes simplex type 1 labialis. Journal of Medical Virology, v. 92, n. 12, MAY 2020. (12/07251-6, 17/24356-0)