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Influence of an antibacterial triclosan based monomer on properties of an experimental resin composite and on characteristics of carigenic biofilm

Grant number: 12/10750-4
Support Opportunities:Regular Research Grants
Duration: March 01, 2013 - February 28, 2015
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal Investigator:Regina Maria Puppin Rontani
Grantee:Regina Maria Puppin Rontani
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil


The aim of this study is to evaluate the effect of the incorporation of triclosan-based antimicrobial monomer in an experimental composite resin, concerning some microbiological (antibacterial and cytotoxicity effect), physical (conversion degree) and mechanical (compressive strength, flexural strength, hardness Knoop and elasticity modulus) properties, and the influence of the restorative experimental composite in cariogenic biofilms and the composite degradation resistance under S. mutans biofilm. Initially, the triclosan-based antimicrobial monomer will be incorporated into the experimental composite resin. Secondly, it will be determined the antimicrobial and cytotoxicity properties of the composite using inhibition halo and cell viability tests. Then, the conversion degree will be determined by infrared spectroscopy (FTIR) and cross-linking density, and mechanical properties will be evaluated. Afterwards, it will be determined the restorative materials influence on S. mutans biofilm and the effect of the surface biodegradation of these materials. The surface degradation will be determined by roughness, surface hardness (KHN) and morphology analysis by scanning electron microscopy - SEM. The influence of experimental composite in the biofilm will be evaluated by Confocal Laser Scanning Microscopy-CLSM. In addition, the biofilm formed on composite surfaces will be evaluated using morphology, biovolume and roughness using COMSTAT software. The results will be submitted to appropriate statistical tests, considering a significance level of 5%. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE PAULA, ANDREIA BOLZAN; TAPARELLI, JESUS ROBERTO; BRUSCHI ALONSO, ROBERTA CAROLINE; INNOCENTINI-MEI, LUCIA HELENA; PUPPIN-RONTANI, REGINA M.. Synthesis and application of triclosan methacrylate monomer in resin composites. CLINICAL ORAL INVESTIGATIONS, v. 23, n. 2, p. 965-974, . (12/10750-4, 11/14151-5)
ANDREIA BOLZAN DE PAULA; ROBERTA CAROLINE BRUSCHI ALONSO; JESUS ROBERTO TAPARELLI; JÉSSICA RODRIGUES CAMASSARI; LÚCIA HELENA INNOCENTINI-MEI; LOURENÇO CORRER-SOBRINHO; REGINA M. PUPPIN-RONTANI. Influence of the incorporation of triclosan methacrylate on the physical properties and antibacterial activity of resin composite. Journal of Applied Oral Science, v. 27, . (12/10750-4)
DE SOUZA ARAUJO, ISAAC JORDAO; DE PAULA, ANDREIA BOLZAN; BRUSCHI ALONSO, ROBERTA CAROLINE; TAPARELLI, JESUS ROBERTO; INNOCENTINI MEI, LUCIA HELENA; STIPP, RAFAEL NOBREGA; PUPPIN-RONTANI, REGINA MARIA. A novel Triclosan Methacrylate-based composite reduces the virulence of Streptococcus mutans biofilm. PLoS One, v. 13, n. 4, . (12/10750-4)

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