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Translational neuroscience of Alzheimer's disease: preclinical and clinical studies of b-amyloid peptide and other biomarkers

Grant number: 12/50329-6
Support type:Research Projects - Thematic Grants
Duration: December 01, 2012 - November 30, 2018
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Geraldo Busatto Filho
Grantee:Geraldo Busatto Filho
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:Carlos Alberto Buchpiguel ; Luiz Roberto Giorgetti de Britto ; Vitor Tumas
Associated scholarship(s):18/16610-6 - Functional neuroimaging in healthy elderlies: correlation between Resting State Functional Magnetic Resonance Imaging and amyloid accumulation mapping via PiB-PET, BP.MS
17/04044-3 - Translational neuroscience of Alzheimer's Disease: preclinical and clinical studies of b-amyloid peptide and other biomarkers, BP.TT
13/16364-1 - NADPH oxidase in the model of Alzheimer's Disease by intracerebroventricular injection of streptozotocin, BP.IC

Abstract

The diagnosis of Alzheimer's disease (AD), a great public health problem, is imprecise and delayed (since the neurodegenerative processes begin years before the appearance of symptoms). The validation of AD biomarkers has the potential to afford early diagnosis and novel treatments. This project aims to investigate, in a multidisciplinary and translational fashion, the accumulation of b-amyloid peptide (the pathological hallmark of AD) and its associated brain changes (macroscopic and molecular), bringing together several 1A-B CNPq scientists and other researchers, members of 11 post-graduate teaching areas (7 of which level 6-7 CAPES), distributed across four centers of the Universidade de São Paulo - Faculdade de Medicina da USP (FMUSP), Faculdade de Medicina de Ribeirão Preto (FMRP), Instituto de Ciências Biomédicas (ICB) and Instituto de Psicologia (IP). We will carry out clinical studies with large samples, and these will be integrated with basic neuroscience investigations aimed at detailing the molecular processes underlying biomarker changes associated with the progression of AD and its treatment. These studies will involve: the use, for the first time in Brazil, of the b-amyloid tracer 11 C-PIB with positron emission tomography (PET); studies on healthy and pathological brain aging integrating the FMUSP-FMRP groups and evaluating 500 elderly individuals (subjects with minor cognitive impairment, AD and healthy controls) using magnetic resonance imaging and other biomarkers (cerebrospinal fluid / blood); application of novel pattern recognition methods for the extraction of statistical data evaluating the relative value of different biomarkers in regard to diagnostic accuracy, thus helping to delineate individualized "neurobiological signatures", within a perspective of personalized Medicine; and experiments with animal models and cell cultures investigating the impact of the exposure to b-amyloid in the brain, as well as changes in associated biochemical and electrophysiological processes. By endorsing the interaction of this group of scientists in the short and long term, we aim to increase the impact of our publications, pave the way for innovative drug trials with disease-modifying agents, and promote technological innovation in terms of diagnostic processes and patenting of novel pharmacological agents. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
A method for detecting peptide accumulation linked to Alzheimer’s is validated in Brazil 
Articles published in other media outlets (15 total):
More itemsLess items
A Method for Detecting Peptide Accumulation Linked to Alzheimer’s Is Validated in Brazil 
Validan un método para detectar la acumulación de un péptido ligado al Mal de Alzheimer 
Validan un método para detectar la acumulación de un péptido ligado al Mal de Alzheimer 
Validan en brasil un método para detectar la acumulación de un péptido ligado al alzhéimer 
Confirman avance contra el Alzheimer 
Método para detectar acúmulo de peptídeo ligado ao Alzheimer é validado no Brasil 
Método para detectar acúmulo de peptídeo ligado ao Alzheimer é validado 
Grupo de pesquisadores valida método que pode revolucionar o diagnóstico de Alzheimer 
Método para detectar acúmulo de peptídeo ligado ao Alzheimer é validado no Brasil 
Alzheimer: método para detectar acúmulo de peptídeo é validado no Brasil 
Método para detectar acúmulo de peptídeo ligado ao Alzheimer é validado no Brasil 
Método para detectar acúmulo de peptídeo ligado ao Alzheimer é validado no Brasil 
Método para detectar acúmulo de peptídeo ligado ao Alzheimer é validado no Brasil 
Pesquisadores da FMUSP validam metodologia para detecção do Alzheimer 
Método que diferencia Alzheimer de outras demências é validado no país 

Scientific publications (14)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GUIMARAES MARQUES, MARCIA JONATHAS; REAL, CAROLINE CRISTIANO; VICTORINO, DANIELLA BALDUINO; BRITTO, LUIZ ROBERTO; CAVALHEIRO, ESPER ABRAO; SCORZA, FULVIO ALEXANDRE; FERRAZ, HENRIQUE BALLALAI; SCORZA, CARLA ALESSANDRA. Endogenous protection against the 6-OHDA model of Parkinson's disease in the Amazonian rodent Proechimys. Neuroscience Letters, v. 709, SEP 14 2019. Web of Science Citations: 1.
SIMON, SHARON S.; HAMPSTEAD, BENJAMIN M.; NUCCI, MARIANA P.; DURAN, FABIO L. S.; FONSECA, LUCIANA M.; MARTINO, MARIA DA GRACA M.; AVILA, RENATA; PORTO, FABIO H. G.; BRUCKI, SONIA M. D.; MARTINS, CAMILA B.; TASCONE, LYSSANDRA S.; AMARO JR, EDSON; BUSATTO, GERALDO F.; BOTTINO, CASSIO M. C. Cognitive and Brain Activity Changes After Mnemonic Strategy Training in Amnestic Mild Cognitive Impairment: Evidence From a Randomized Controlled Tria. FRONTIERS IN AGING NEUROSCIENCE, v. 10, NOV 13 2018. Web of Science Citations: 1.
LUIZ K. FERREIRA; JANE M. RONDINA; RODRIGO KUBO; CARLA R. ONO; CLAUDIA C. LEITE; JERUSA SMID; CASSIO BOTTINO; RICARDO NITRINI; GERALDO F. BUSATTO; FABIO L. DURAN; CARLOS A. BUCHPIGUEL. Support vector machine-based classification of neuroimages in Alzheimer’s disease: direct comparison of FDG-PET, rCBF-SPECT and MRI data acquired from the same individuals. Revista Brasileira de Psiquiatria, v. 40, n. 2, p. -, Jun. 2018.
FERREIRA, LUIZ K.; RONDINA, JANE M.; KUBO, RODRIGO; ONO, CARLA R.; LEITE, CLAUDIA C.; SMID, JERUSA; BOTTINO, CASSIO; NITRINI, RICARDO; BUSATTO, GERALDO F.; DURAN, FABIO L.; BUCHPIGUEL, CARLOS A. Support vector machine-based classification of neuroimages in Alzheimer's disease: direct comparison of FDG-PET, rCBF-SPECT and MRI data acquired from the same individuals. Revista Brasileira de Psiquiatria, v. 40, n. 2, p. 181-191, APR-JUN 2018. Web of Science Citations: 2.
TASCONE, LYSSANDRA DOS SANTOS; PAYNE, MARTHA E.; MACFALL, JAMES; AZEVEDO, DIONISIO; DE CASTRO, CLAUDIO CAMPI; STEFFENS, DAVID C.; BUSATTO, GERALDO F.; BOTTINO, CASSIO M. C. Cortical brain volume abnormalities associated with few or multiple neuropsychiatric symptoms in Alzheimer's disease. PLoS One, v. 12, n. 5 MAY 8 2017. Web of Science Citations: 2.
RZEZAK, PATRICIA; LIMA, ELLEN MARISE; GARGARO, ANA CAROLINA; COIMBRA, ERICA; DE VINCENTIIS, SILVIA; VELASCO, TONICARLO RODRIGUES; LEITE, JOAO PEREIRA; BUSATTO, GERALDO F.; VALENTE, KETTE D. Everyday memory impairment in patients with temporal lobe epilepsy caused by hippocampal sclerosis. Epilepsy & Behavior, v. 69, p. 31-36, APR 2017. Web of Science Citations: 8.
FERREIRA, LUIZ KOBUTI; BROCANELLO REGINA, ANA CAROLINA; KOVACEVIC, NATASA; MORAIS MARTIN, MARIA DA GRACA; SANTOS, PEDRO PAIM; CARNEIRO, CAMILA DE GODOI; KERR, DANIEL SHIKANAI; AMARO, JR., EDSON; MCINTOSH, ANTHONY RANDAL; BUSATTO, GERALDO F. Aging Effects on Whole-Brain Functional Connectivity in Adults Free of Cognitive and Psychiatric Disorders. CEREBRAL CORTEX, v. 26, n. 9, p. 3851-3865, SEP 2016. Web of Science Citations: 33.
RZEZAK, PATRICIA; LIMA, ELLEN MARISE; PEREIRA, FABRICIO; GARGARO, ANA CAROLINA; COIMBRA, ERICA; DE VINCENTIIS, SILVIA; VELASCO, TONICARLO RODRIGUES; LEITE, JOAO PEREIRA; BUSATTO, GERALDO F.; VALENTE, KETTE D. Decision-making in patients with temporal lobe epilepsy: Delay gratification ability is not impaired in patients with hippocampal sclerosis. Epilepsy & Behavior, v. 60, p. 158-164, JUL 2016. Web of Science Citations: 4.
LUÍS GUSTAVO RIBEIRO; GERALDO BUSATTO FILHO. Voxel-based morphometry in Alzheimers disease and mild cognitive impairment: Systematic review of studies addressing the frontal lobe. Dement. Neuropsychol., v. 10, n. 2, p. 104-112, Jun. 2016.
RZEZAK, PATRICIA; SQUARZONI, PAULA; DURAN, FABIO L.; FERRAZ ALVES, TANIA DE TOLEDO; TAMASHIRO-DURAN, JAQUELINE; BOTTINO, CASSIO M.; RIBEIZ, SALMA; LOTUFO, PAULO A.; MENEZES, PAULO R.; SCAZUFCA, MARCIA; BUSATTO, GERALDO F. Relationship between Brain Age-Related Reduction in Gray Matter and Educational Attainment. PLoS One, v. 10, n. 10 OCT 16 2015. Web of Science Citations: 11.
SONVENSO, DANIELE KANASHIRO; ITIKAWA, EMERSON NOBUYUKI; SANTOS, MARCELO VOLPON; SANTOS, LEONARDO ALEXANDRE; TREVISAN, ANA CAROLINA; BIANCHIN, MARINO MUXFELDT; PITELLA, FELIPE ARRIVA; KATO, MERY; CARLOTTI, JR., CARLOS GILBERTO; FILHO BUSATTO, GERALDO; VELASCO, TONICARLO RODRIGUES; SANTOS, ANTONIO CARLOS; LEITE, JOAO PEREIRA; SAKAMOTO, AMERICO CEIKI; MACHADO, HELIO RUBENS; NUNES, ALTACILIO APARECIDO; WICHERT-ANA, LAURO. Systematic review of the efficacy in seizure control and safety of neuronavigation in epilepsy surgery: The need for well-designed prospective studies. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, v. 31, p. 99-107, SEP 2015. Web of Science Citations: 2.
FERREIRA, LUIZ K.; TAMASHIRO-DURAN, JAQUELINE H.; SQUARZONI, PAULA; DURAN, FABIO L.; ALVES, TANIA C.; BUCHPIGUEL, CARLOS A.; BUSATTO, GERALDO F. The link between cardiovascular risk, Alzheimer's disease, and mild cognitive impairment: support from recent functional neuroimaging studies. Revista Brasileira de Psiquiatria, v. 36, n. 4, p. 344-357, OCT-DEC 2014. Web of Science Citations: 4.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.