Vouacapans and geranilgeraniol synergic effect evaluation on nociceptive pain, pharmacokinetic and preclinical toxicological studies

• Grant number: 12/19661-4
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2013
• End date: February 28, 2015
• Field of knowledge: Health Sciences - Pharmacy - Medicines Analysis and Control
• Principal Investigator: Mary Ann Foglio
• Grantee: Mary Ann Foglio
• Host Institution: Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA). Universidade Estadual de Campinas (UNICAMP). Paulínia , SP, Brazil
• Associated researchers: João Ernesto de Carvalho

Abstract

This proposal is a continuation of our previous research work that identified geranylgeraniol and voucapan compounds as the major active principles involved with the antinociceptive activity. The studies proposed herein will permit to establish the sinergic relationships that take place, undergo pharmacokinetic studies of the pure compounds to further establish conditions to study the pharmakcokinetics of the standarized extract. Also preclinical cronic toxicity studies will be undertaken to establish safety doses to be employed. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE PAIVA, PAULA P.; NUNES, JULIA H. B.; NONATO, FABIANA R.; RUIZ, ANA L. T. G.; ZAFRED, RAFAEL R. T.; SOUSA, ILZA M. O.; OKUBO, MARCIA Y.; KAWANO, DANIEL F.; MONTEIRO, PAULA A.; FOGLIO, MARY A.; et al. In Silico, In Vitro, and In Vivo Antitumor and Anti-Inflammatory Evaluation of a Standardized Alkaloid-Enriched Fraction Obtained fromBoehmeria caudataSw. Aerial Parts. Molecules, v. 25, n. 17, SEP 2020. (17/21801-2, 12/19661-4, 11/22458-3, 14/06636-7, 11/22457-7)

DE PAIVA, PAULA P.; NUNES, JULIA H. B.; NONATO, FABIANA R.; RUIZ, ANA L. T. G.; ZAFRED, RAFAEL R. T.; SOUSA, ILZA M. O.; OKUBO, MARCIA Y.; KAWANO, DANIEL F.; MONTEIRO, PAULA A.; FOGLIO, MARY A.; et al. In Silico, In Vitro, and In Vivo Antitumor and Anti-Inflammatory Evaluation of a Standardized Alkaloid-Enriched Fraction Obtained fromBoehmeria caudataSw. Aerial Parts. Molecules, v. 25, n. 17, p. 20-pg., 2020-09-01. (12/19661-4, 17/21801-2, 11/22457-7, 11/22458-3, 14/06636-7)

SPINDOLA, HUMBERTO M.; GRANDO, ROGERIO; FIGUEIREDO, MARIANA C.; BASTING, ROSANA; QUEIROZ, N. C. A.; DE FATIMA, ANGELO; DE CARVALHO, JOAO E.; WANG, ZAIJIE J.; FOGLIO, M. A.. Derivatives of furanditerpenes from Pterodon genus: Pharmacological studies disclose their potential as chronic pain relief in mice. European Journal of Pharmacology, v. 804, p. 68-77, JUN 5 2017. (10/09287-2, 12/19661-4, 12/03652-6)

DA SILVA SOUZA, VANESSA HELENA; BASTING, ROSANNA TARKANY; DE OLIVEIRA SOUSA, ILZA MARIA; ALMEIDA QUEIROZ, NUBIA DE CASSIA; DE CARVALHO, JOAO ERNESTO; FOGLIO, MARY ANN. Evaluation of non-clinical toxicity of extract and vouacapans from fruits ofPterodon pubescensBenth. DRUG AND CHEMICAL TOXICOLOGY, v. 45, n. 3, p. 14-pg., 2020-09-22. (12/19661-4)

Filed patent(s) as a result of this research project