Advanced search
Start date

The viteline enigma

Grant number: 08/58811-6
Support type:Research Projects - Thematic Grants
Duration: September 01, 2009 - August 31, 2014
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Maria Angelica Miglino
Grantee:Maria Angelica Miglino
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:Patricia Cristina Baleeiro Beltrão Braga ; Paula de Carvalho Papa Keohane
Associated grant(s):11/10714-5 - Plan activity browser Andrea Maria Mess november 2011/november 2012, AV.EXT
Associated scholarship(s):11/03656-9 - Obtainment, cultivation and expansion of stem cells from the yolk sac of pigs (SUS scrofa), BP.MS
11/04916-4 - Characterization of hematopoietic stem cell of bovine embryo yolk sac, BP.MS
10/01477-7 - Proteomic analysis on bovine embryonic intestine, BP.MS
10/09501-4 - Comparative analysis of yolk sac of bovine embryos with 30 days of pregnancy from artificial insemination and in vitro fertilization, BP.IC
09/01124-0 - Function of the PROGRANULINE growth factor in the hepatic lineage cell differentiation and proliferation during the embryo development of Fisher 344 rats, BP.MS


The successive different phases of gestation are characterized by two clearly distinct parts. The first one is related to the beginning of the gestation and means the first three months of pregnancy in human important events just as embryogenesis, placentation and organogenesis occur during this period. Some evidence found in animal models suggests problems could reflect early or late interruption of gestation and other deleterious effects during this phase of the development. The second phase is the fetal development. The relation and regulation of functional mechanisms evolved in the beginning of the gestation are still unknown. The yolk sac is the only embryonic annex present in all species. Therefore, the histotrophic nutrition, celomic obliteration, yolk sac degeneration, intense yolk sac vascularization, yolk sac placentation, yolk sac absorption, cellular yolk sac differentiation, yolk sac inversion and specific yolk sac functions including synthesis, storage and transport in the yolk sac, yolk sac plasticity and specialization and the genes evolved in the yolk sac connections need further information. For this reason, with the experience of who has devoted more than 20 years to study placenta and placentation in many animal models, this research group presents this proposal. These researchers want now study and correlate data and ideas around the yolk sac enigma. Initially, the group focus will be on the morphofunctional analysis related to the yolk sac activity in animal models with compared to without yolk sac placentation. Furthermore, a proteomic analysis of the yolk sac, the inversion mechanisrn, absorption, introspection, specialization and transport in the yolk sac will also be studied. Culture of cells from yolk sac or from progenitor cells from the yolk sac will be performed aiming to establish yolk sac cell lines and to study the plasticity of the in vitro yolk sac cells in vitro, including pre clinical tests for cellular therapy in genetic or other animal diseases. Moreover, this proposal includes the study of the VEGF function in the formation of the yolk sac, the differentiation and migration of the different cell types, and the study of the genes evolved on the yolk sac connections. (AU)

Articles published in Agência FAPESP Newsletter about the research grant
Cell therapy reduces liver regeneration time  

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE ASSIS NETO, ANTONIO CHAVES; DE OLIVEIRA, FRANCELIUSA DELYS; PIEMONTE CONSTANTINO, MARIA VITORIA; MIGLINO, MARIA ANGELICA. Morphology and Involution of the Yolk Sac during Early Gestation Bovine (Bos indicus). Acta Scientiae Veterinariae, v. 40, n. 4 2012. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: