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Flow rate, buffer capacity and biochemistry composition of the saliva of children and adolescents with Hodgkin's lymphoma

Grant number: 12/14699-3
Support Opportunities:Regular Research Grants
Duration: April 01, 2013 - March 31, 2015
Field of knowledge:Health Sciences - Dentistry - Pediatric Dentistry
Principal Investigator:Marines Nobre dos Santos Uchôa
Grantee:Marines Nobre dos Santos Uchôa
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
Associated researchers:Lenita Marangoni Lopes


Saliva has several protective properties to the oral cavity. However, many diseases can affect the yield and composition of saliva, resulting in xerostomia. Studies show that one of the causes of dry mouth is radiation therapy in head and neck used to treat cancer. Among the neoplasms in pediatric patients that include in their treatment protocols radiotherapy, we highlight the Hodgkin's lymphoma, which frequently affects cervical ganglion chains can trigger salivary alterations. However, it is not known from previous studies that have researched on xerostomia in children and adolescents with this disease. Thus, this study will evaluate: salivary flow at rest and stimulated, pH, buffering capacity, mineral composition (Ca, P) and ELISA analysis of saliva of pediatric patients diagnosed with Hodgkin lymphoma and radiation in supraclavicular and compare them to a control group. To this end, the study will be conducted with 15 children aged 6 to 18 years, suffering from Hodgkin's lymphoma. The saliva is collected at the beginning, every 1000cGy complete, and at the end of radiotherapy. Will be used as a control 15 healthy children the same age. The volume of saliva collected in 5 minutes (stimulated saliva) and 10 minutes (unstimulated saliva), saliva flow will be estimated. Saliva collected will be used for evaluation of pH and buffer capacity, determination of mineral content by atomic absorption spectrophotometry. Will be held the enzyme immunoassay for identification of proteins: immunoglobulin A, lactoferrin, lactoperoxidase, mucin and amylase. The results will be statistically analyzed by ANOVA and Kruskal-Wallis test with a significance level of 5%. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARANGONI-LOPES, L.; RODRIGUES, L. P.; MENDONCA, R. H.; NOBRE-DOS SANTOS, M.. Radiotherapy changes salivary properties and impacts quality of life of children with Hodgkin disease. ARCHIVES OF ORAL BIOLOGY, v. 72, p. 99-105, . (12/02858-0, 12/14699-3)

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