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Flow rate, buffer capacity, biochemistry composition of the saliva of children with lymphoma in Boldrini children center

Grant number: 12/02858-0
Support type:Scholarships in Brazil - Master
Effective date (Start): May 01, 2012
Effective date (End): March 31, 2014
Field of knowledge:Health Sciences - Dentistry - Pediatric Dentistry
Principal researcher:Marines Nobre dos Santos Uchôa
Grantee:Lenita Marangoni Lopes
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil


Saliva is an important protective factor for oral diseases due to their properties such as buffering capacity, formation of acquired pellicle and remineralizing enamel by means of Ca and P. However, many diseases can affect the production and composition of saliva, resulting in xerostomia. Estudos show that the main cause of dry mouth is radiation therapy in head and neck used to treat cancer. This is due to reduced salivary flow, and biochemical changes in the composition of saliva. The pediatric cancer is highly prevalent and important among them is the second most common lymphoma. However, it is not known from previous studies that have researched on xerostomia in children with lymphoma. Therefore, the objective of this study will evaluate the following properties of saliva: salivary flow, pH, buffering capacity, mineral composition (Ca, Pi) and total protein in pediatric patients diagnosed with lymphoma and who are under radiotherapy. There will be collection of stimulated saliva of 15 children aged 10 to 15 years, suffering from lymphoma Institute Infantil Boldrini. Will be used as a control 15 healthy children. Due to the volume of saliva collected in five minutes, will be estimated salivary flow in mL / min. The saliva collected will be used to evaluate the pH and buffering capacity, by colorimetric testing and determining the mineral content by atomic absorption spectrophotometry. Will determine the amount of total protein by the Lowry method, the activity of salivary amylase and electrophoresis to identify the proteins present. Will apply a statistical test adjusting in order to compare children with cancer with the control group.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARANGONI-LOPES, L.; RODRIGUES, L. P.; MENDONCA, R. H.; NOBRE-DOS SANTOS, M. Radiotherapy changes salivary properties and impacts quality of life of children with Hodgkin disease. ARCHIVES OF ORAL BIOLOGY, v. 72, p. 99-105, DEC 2016. Web of Science Citations: 3.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LOPES, Lenita Marangoni. Flow rate, pH and buffering capacity of saliva of children with Hodgkin's disease trated with radiotherapy : prospective study. 2014. Master's Dissertation - Universidade Estadual de Campinas. Faculdade de Odontologia de Piracicaba.

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