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| Author(s): |
Lenita Marangoni Lopes
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | Piracicaba, SP. |
| Institution: | Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba |
| Defense date: | 2014-03-28 |
| Examining board members: |
Marinês Nobre dos Santos;
Cinthia Pereira Machado Tabchoury;
Tatiane Marega
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| Advisor: | Marinês Nobre dos Santos |
| Abstract | |
Saliva is an important protective factor for oral diseases due to properties such as clearance by salivary flow, and maintenance of pH within acceptable levels by buffer capacity. However, many factors can affect saliva production, which can result in hypossalivation and symptoms of dry mouth, the xerostomia. Studies have shown that one of the causes of hypossalivation is radiotherapy of head and neck used to treat cancer. Among children's neoplasms that include in their treatment protocols the radiotherapy of cervical region, we highlight the Hodgkin's lymphoma, which often affects cervical ganglion. Thus, the first aim of this study was to investigate if the radiotherapy treatment has any effect on the salivary flow rate, pH and buffering capacity of stimulated and unstimulated saliva of children with Hodgkin's lymphoma. The second aim of our study was to evaluate if there is any correlation between these salivary parameters and some areas that express the quality of life before, during and after radiotherapy treatment. To do so, stimulated and unstimulated saliva was collected and the H&N35 questionnaire was applied to 10 children and adolescents aging 6-16 years old, with Hodgkin's lymphoma before the start of treatment (baseline), after the 1000 and 2000 cGy doses were completed, and after 1, 2 and 3 months of the end of the radiotherapy. As a control group, a single saliva collection was performed in 10 healthy children of the same age group. The volume of saliva collected was divided by the time of collection to estimate the salivary flow rate. The collected saliva was used to evaluate the pH and the buffer capacity by the titration method. The questionnaire was interpreted according to recommendations of the European Organization for Research and Treatment of Cancer (EORTC). The results of the study showed that when compared to control group, an decrease unstimulated salivary flow rate was found after the dose of 1000 cGy and after 1 month but no difference among groups was found. Stimulated salivary flow rate was significantly lower at baseline as well as after the doses of 1000, 2000 cGy and 1, 2 and 3 months after treatment when compared to control group. In the same way, a significantly lower stimulated salivary flow rate was observed after the dose of 1000 cGy and 1 month after treatment when compared to baseline. The pH of unstimulated saliva decreased after 3 months as compared to control group but no difference was found among salivary pH at baseline and any other group. The pH of stimulated saliva was lower after 1 and 3 months when compared to control group. The buffering capacity of unstimulated and stimulated saliva was reduced after the dose of 2000 cGy. The volunteers reported a greater intensity of dry mouth and pain after doses of 1000 and 2000 cGy. Moreover, for unstimulated saliva, except for the absence of correlation between pH and pain after the dose of 2000 cGy, a significant correlation was found among pain, dry mouth and all investigated variables in all phases. For stimulated saliva no correlation between pH and pain after the dose of 2000 cGy and 2 months after treatment could be detected. Then, it can be concluded that the radiotherapic protocol, to which the volunteers were submitted, produced changes in salivary flow rate and buffering capacity of saliva and that these changes negatively impacted the quality of life regarding the intensity of dry mouth and pain sensation in the oral cavity of evaluated children (AU) | |
| FAPESP's process: | 12/02858-0 - Flow rate, buffer capacity, biochemistry composition of the saliva of children with lymphoma in Boldrini children center |
| Grantee: | Lenita Marangoni Lopes |
| Support Opportunities: | Scholarships in Brazil - Master |