Irisin behaviour in rats submitted to paradoxical sleep deprivation and restriction
| Grant number: | 12/09700-2 |
| Support type: | Regular Research Grants |
| Duration: | May 01, 2013 - April 30, 2015 |
| Field of knowledge: | Health Sciences - Medicine |
| Principal Investigator: | Marco Túlio de Mello |
| Grantee: | Marco Túlio de Mello |
| Home Institution: | Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil |
| Assoc. researchers: | Andrea Maculano Esteves ; Camila Maria de Melo ; Francieli Ruiz da Silva ; Juliana Martuscelli da Silva Prado ; Sandra Souza de Queiroz ; Sergio Tufik |
Abstract
Sleep restriction is now recognized as an increasingly common condition inherent to modern society, and one that in many ways, is detrimental to physiological systems. Although sleep is now viewed by a significant body of researchers as being essential for the biological systems homeostasis, the full impact of sleep restriction on health, medical disorders and well-being remains largely unknown. In this sense, the experimental sleep restriction has been considered an important toll to clarify the consequences of chronic sleep debt, given the large number of physiological changes associated with sleep loss, particularly with respect to metabolism, motor and cognitive performance and inflammatory profile. Beyond the experimental approach, it is essential also to study the consequences of sleep restriction experienced by individuals with sleep disorders and shift workers, since the sleep quality of people in these situations demonstrates significant impairment. In order to attend these different aspects, the aim of this project is to access the consequences of sleep restriction to the physiological and inflammatory profile using three approaches: Approach 1: Effects of sleep restriction in healthy subjects. Approach 2: Effects of sleep restriction in subjects with sleep apnea. Approach 2: Effects of sleep restriction in shift workers. (AU)