Identification of markers of imune and inflammatory response in experimentally induced viral encephalitis in a murine model

• Grant number: 12/24769-9
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2013
• End date: April 30, 2015
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal Investigator: Paulo César Maiorka
• Grantee: Paulo César Maiorka
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Animal models in laboratory species are fundamental for coprehension of pathologic processes that involve experimental infection. Encephalitis are severe pathologic processes, immune and inflammatory responses are poorly understood and can participate in the pathogenesis of these diseases. Identification of patterns or markers of immune and inflammatory response are detrimental to comprehend mediation of thes processes. Murine Models have been used to elucidate immune and inflammatory response in viral encephalitis. Factos like neurovirulence and neuropathogenesis are still little understood in samples isolated from spontaneous diseases of domestic animals. This project aims to study and identify markers of immune and inflammatory response in viral encephalitis experimentally induced in mice. Citokyne participation and regulation of cellular response are important factos in evolution of encephalitis. Evaluation of these factos can reveal markeres of the process and aid in comprehension of the lesion developed by the ethiologic agent, as well as the participation of immune system in the evolution of these diseases that are lethal to the animals. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MESQUITA, LEONARDO P.; HORA, ALINE S.; DE SIQUEIRA, ADRIANA; SALVAGNI, FERNANDA A.; BRANDAO, PAULO E.; MAIORKA, PAULO C.. Glial response in the central nervous system of cats with feline infectious peritonitis. JOURNAL OF FELINE MEDICINE AND SURGERY, v. 18, n. 12, p. 1023-1030, DEC 2016. (12/24769-9, 13/00629-6)

MESQUITA, LEONARDO PEREIRA; AREVALO, ANDRESSA FERRARI; ZANATTO, DENNIS A.; MIYASHIRO, SAMANTHA IYE; SEQUETIN CUNHA, ELENICE MARIA; CUSTODIO DE SOUZA, MARIA DO CARMO; CASSARO VILLALOBOS, ELIANA MONTEFORTE; CABRERA MORI, CLAUDIA MADALENA; MAIORKA, PAULO CESAR; MORI, ENIO. Equine herpesvirus type 1 induces both neurological and respiratory disease in Syrian hamsters. Veterinary Microbiology, v. 203, p. 117-124, MAY 2017. (12/24769-9, 16/09396-2)

MESQUITA, L. P.; COSTA, R. C.; FUSUMA, M. M.; BRUHN, F. R. P.; MORI, E.; PITUCO, E. M.; MORI, C. M. C.; WEIBLEN, R.; MAIORKA, P. C.. Susceptibility of mice to bovine herpesvirus type 5 infection in the central nervous system. VETERINARY RESEARCH COMMUNICATIONS, v. 41, n. 4, p. 279-288, DEC 2017. (12/24769-9, 13/00629-6)