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Evaluation of Immune and Inflammatory Responses in Experimentally Induced Encephalitis in Mice by Bovine Herpesvirus 5 (BHV-5) and Vesicular Estomatitis Virus (VSV) Infection.

Grant number: 13/00629-6
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2013
Effective date (End): September 30, 2016
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal Investigator:Paulo César Maiorka
Grantee:Leonardo Pereira Mesquita
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):14/20631-8 - Chemokine responses in brain of deer mouse (Peromyscus maniculatus) experimentally infected with vesicular stomatitis virus, BE.EP.DR


The bovine herpesvirus type 5 (BHV-5) is an important infectious agent that causes meningoencephalitis in young cattle. The infection due to BHV-5 induces different levels in severity of neurological disease, which depends on the host and viral factors. Similarly, the vesiscular stomatitis virus (VSV) affects primarily cattle, and the infection by this virus is characterized by the formation of vesicular lesions. In murine model the VSV can infect neuroepithelial cells, thus representing a model for acute neurotropic infections caused by viruses. Classically, the rabbit has been used as a experimental model for the BHV-5 infection and the first attempts to use a mouse model for the infection were unsuccessful. However, recently, the use of different strains of young mice allowed the infection by another types of animal herpesviruses. Murine models have been used for the study of the alterations on the central nervous system caused by infections by these type of viruses, once the use of cattle for the investigation of these diseases is generally laborious, expensive and difficult to standardize. Different types of mice strains and the genetically modified mice have demonstrated to be potential tools for the study of etiopathogenesis of viral encephalitis. The central nervous system has unique characteristics during the inflammatory responses due to viral infection, and during the infection, the astrocytes can become activated and express higher levels of glial fibrillary acidic protein (GFAP). Given the above, the purpose of the present study is to evaluate the kinectics of the inflammatory process, as well as the involvement of the glial cells and cytokines in the development of the experimentally encephalitis induced by BHV-5 and VSV in different strains of mice.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MESQUITA, L. P.; COSTA, R. C.; FUSUMA, M. M.; BRUHN, F. R. P.; MORI, E.; PITUCO, E. M.; MORI, C. M. C.; WEIBLEN, R.; MAIORKA, P. C.. Susceptibility of mice to bovine herpesvirus type 5 infection in the central nervous system. VETERINARY RESEARCH COMMUNICATIONS, v. 41, n. 4, p. 279-288, . (12/24769-9, 13/00629-6)
MESQUITA, LEONARDO P.; HORA, ALINE S.; DE SIQUEIRA, ADRIANA; SALVAGNI, FERNANDA A.; BRANDAO, PAULO E.; MAIORKA, PAULO C.. Glial response in the central nervous system of cats with feline infectious peritonitis. JOURNAL OF FELINE MEDICINE AND SURGERY, v. 18, n. 12, p. 1023-1030, . (12/24769-9, 13/00629-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MESQUITA, Leonardo Pereira. Evaluation of immune and inflammatory responses in experimentally induced encephalitis in mice caused by vesicular stomatitis virus and bovine herpesvirus type 5. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.

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