Platelet rich plasma and bone marrow in minimally invasive osteosynthesis of tibia in dogs

• Grant number: 12/20642-4
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2013
• End date: May 31, 2015
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Bruno Watanabe Minto
• Grantee: Bruno Watanabe Minto
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
• Associated researchers: Cláudia Valéria Seullner Brandão

Abstract

Generally the fractures of long bones are treated by open reduction and anatomical fragment stabilization using external fixators, intramedullary pins, locking nails, bone plates or even combinations of them. These techniques commonly require extensive dissection of the adjacent soft tissue and periosteum damage, that may cause an increased risk of complications, including infection, delayed union and nonunion. Thus, a less invasive approach has been pursued, especially to cause less trauma to soft tissues without, however, affect the stability of the fracture. The minimally invasive plate osteosynthesis (MIPO) has become widely accepted for the treatment of fractures, since it can provide indirectly reduction, preservation of the initial hematoma and minimal soft tissue damage. Biomaterials such as platelet rich plasma (PRP)and bone marrow aspirate (MO) are able to help bone healing. The aim of this study is to evaluate the bone healing after a minimally invasive plate osteosynthesis associated with percutaneous injection of PRP and MO, into the focus of tibial fractures in dogs. Will be used twenty-four dogs from the Hospital Veterinário Governador Laudo Natel - UNESP- Jaboticabal surgical routine. The dogs will be evaluated by an ambulation, swelling intensity, radiographic examination and densitometry on 15, 30, 60, 90 and 120 days postoperatively. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERNANDES FILGUEIRA, FABRICIA GEOVANIA; MINTO, BRUNO WATANABE; CHUNG, DENISE GRANATO; PRADA, TIAGO CARMAGNI; ROSA-BALLABEN, NATALIE MASSARO; NOGUEIRA CAMPOS, MARIA GABRIELA. Platelet-rich plasma, bone marrow and chitosan in minimally invasive plate osteosynthesis of canine tibia fractures - a randomized study. VETERINARNI MEDICINA, v. 64, n. 7, p. 309-316, 2019. (12/20642-4, 12/16712-7)