Study of the activity of biodrugs, PPARs agonists and natural products with therapeutic potential in atherosclerosis

• Grant number: 12/51316-5
• Support Opportunities: Research Projects - Thematic Grants
• Start date: May 01, 2013
• End date: December 31, 2018
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Dulcineia Saes Parra Abdalla
• Grantee: Dulcineia Saes Parra Abdalla
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant(s): 14/50238-6 - Identification of miRNAs involved in the modulation of angiogenesis-related genes by polyphenols, AP.R
• Associated scholarship(s): 13/22806-7 - Inflammatory response of LDL electronegative mimotope peptides in cells of human and murine immune system, BP.IC

Abstract

The cardiovascular diseases, that have atherosclerosis as their major pathophysiological process, constitute one of the main mundial causes of morbidity and mortality contributing to 30% of deaths world-wide, including in Brazil, with high costs to Public Health as they affect a great part of the economically active population. Atherosclerosis is a multi-factorial chronic immune-inflammatory disease to wich the only available effective therapeutic strategy is based on the control of its risk factors in order to increase the life expectance and quality and to prevent dangerous outcomes as heart infarction, stroke and death. As the current therapeutics of atherosclerosis only allows toavoid the progression of atherosclerotic lesion, the search for new drugs for treating it is crucial. In this context, our research group has developed several strategies focusing on the discovery of drug and biodrugs candidates that can act on the atherosclerotic process. In this project we propose different approaches for the investigation of the actions of recombinant antibody fragments, peptides, and natural and synthetic compounds by using in vitro, ex vivo, in vivo systems, including several cell culture assays and experimental models of atherosclerosis. The activities of these compounds on the immune response, inflammatory process and angiogenesis, that are relevant to atherogenesis and atherosclerotic lesion progression, will be investigated with the major goal to contribute for the developing of new therapeutic strategies for atherosclerosis. (AU)

Scientific publications

(12)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CESAR, FERNANDA A.; RUDNICKI, MARTINA; DE LAS HERAS, BEATRIZ; BOSCA, LISARDO; LIMA, MARIA C. A.; PITTA, IVAN R.; ABDALLA, DULCINEIA S. P.. New indole-thiazolidine attenuates atherosclerosis in LDLr-/- mice. VASCULAR PHARMACOLOGY, v. 71, p. 174-180, AUG 2015. (12/51316-5)

SILVA, JACQUELINE C.; PITTA, MARINA G. R.; PITTA, IVAN R.; KOH, TIMOTHY J.; ABDALLA, DULCINEIA S. P.. New Peroxisome Proliferator-Activated Receptor Agonist (GQ-11) Improves Wound Healing in Diabetic Mice. ADVANCES IN WOUND CARE, v. 8, n. 9, p. 417-428, SEP 1 2019. (12/51316-5, 16/00233-3, 16/16850-1)

SILVA, JACQUELINE C.; CESAR, FERNANDA A.; DE OLIVEIRA, EDSON M.; TURATO, WALTER M.; TRIPODI, GUSTAVO L.; CASTILHO, GABRIELA; MACHADO-LIMA, ADRIANA; DE LAS HERAS, BEATRIZ; BOSCA, LISARDO; RABELLO, MARCELO M.; et al. New PPAR gamma partial agonist improves obesity-induced metabolic alterations and atherosclerosis in LDLr-/- mice. PHARMACOLOGICAL RESEARCH, v. 104, p. 49-60, FEB 2016. (12/14360-6, 12/51316-5)

CAVALCANTE, MARCELA FROTA; ADORNE, MARCIA DUARTE; TURATO, WALTER MIGUEL; KEMMERER, MARINA; UCHIYAMA, MAYARA KLIMUK; CAVAZZIN ASBAHR, ANA CAROLINA; SOARES ALVES, ALINE DE CRISTO; POLISELLI FARSKY, SANDRA HELENA; DREWES, CARINE; SPATTI, MARINA CECILIA; et al. scFv-Anti-LDL(-)-Metal-Complex Multi-Wall Functionalized-Nanocapsules as a Promising Tool for the Prevention of Atherosclerosis Progression. FRONTIERS IN MEDICINE, v. 8, APR 20 2021. (12/51316-5)

SILVA, JACQUELINE CAVALCANTE; BAVESTRELLO, MARGHERITA; GAZZOLA, VALERIO; SPINELLA, GIOVANNI; PANE, BIANCA; GRASSELLI, ELENA; DEMORI, ILARIA; CANESI, LAURA; EMIONITE, LAURA; CILLI, MICHELE; et al. Ischemia-reperfusion damage is attenuated by GQ-11, a peroxisome proliferator-activated receptor (PPAR)-a/? agonist, after aorta clamping in rats. Life Sciences, v. 297, p. 11-pg., 2022-05-15. (12/51316-5, 16/16850-1, 16/00233-3)

CUEVAS, ALEJANDRO; SAAVEDRA, NICOLAS; RUDNICKI, MARTINA; ABDALLA, DULCINEIA S. P.; SALAZAR, LUIS A.. ERK1/2 and HIF1 alpha Are Involved in Antiangiogenic Effect of Polyphenols-Enriched Fraction from Chilean Propolis. Evidence-based Complementary and Alternative Medicine, 2015. (12/51316-5)

RUDNICKI, MARTINA; TRIPODI, GUSTAVO L.; FERRER, RENILA; BOSCA, LISARDO; PITTA, MARINA G. R.; PITTA, IVAN R.; ABDALLA, DULCINEIA S. P.. New thiazolidinediones affect endothelial cell activation and angiogenesis. European Journal of Pharmacology, v. 782, p. 98-106, JUL 5 2016. (12/51316-5, 11/24020-5)

SILVA, JACQUELINE C.; DE OLIVEIR, EDSON M.; TURATO, WALTER M.; TROSSINI, GUSTAVO H. G.; MALTAROLLO, VINICIUS G.; PITTA, MARINA G. R.; PITTA, IVAN R.; DE LAS HERAS, BEATRIZ; BOSCA, LISARDO; RUDNICKI, MARTINA; et al. GQ-11: A new PPAR agonist improves obesity-induced metabolic alterations in LDLr-/- mice. International Journal of Obesity, v. 42, n. 5, p. 1062-1072, JUN 2018. (12/14360-6, 12/51316-5)

ABDALLA, DULCINEIA; CAVALCANTE, MARCELA; TURATO, WALTER; KAZUMA, SORAYA; ADORNE, MARCIA; GUTERRES, SILVIA; POHLMANN, ADRIANA. PET-CT IMAGING OF ATHEROSCLEROSIS IN LDLR-/- MICE TREATED WITH AN ANTI-LDL(-) NANOFORMULATION. ATHEROSCLEROSIS, v. 263, p. 1-pg., 2017-08-01. (12/51316-5)

CUEVAS, ALEJANDRO; SAAVEDRA, NICOLAS; RUDNICKI, MARTINA; ABDALLA, DULCINEIA S. P.; SALAZAR, LUIS A.. ERK1/2 and HIF1 alpha Are Involved in Antiangiogenic Effect of Polyphenols-Enriched Fraction from Chilean Propolis. Evidence-based Complementary and Alternative Medicine, v. 2015, p. 11-pg., 2015-01-01. (12/51316-5)

TRIPODI, GUSTAVO LUIS; PRIETO, MARCELA BACH; ABDALLA, DULCINEIA SAES PARRA. Inflammasome Activation in Human Macrophages Induced by a LDL (-) Mimetic Peptide. Inflammation, v. 43, n. 2, p. 722-730, APR 2020. (12/51316-5)

SANTO FAULIN, TANIZE DO ESPIRITO; KAZUMA, SORAYA MEGUMI; TRIPODI, GUSTAVO LUIS; CAVALCANTE, MARCELA FROTA; WAKASUQUI, FELIPE; PINTO OLIVEIRA, CRISTIANO LUIS; DE SOUZA DEGENHARDT, MAXIMILIA FRAZAO; MICHALOSKI, JUSSARA; GIORDANO, RICARDO JOSE; JACON KETELHUTH, DANIEL FRANCISCO; et al. Proinflammatory Action of a New Electronegative Low-Density Lipoprotein Epitope. BIOMOLECULES, v. 9, n. 8, AUG 2019. (12/51316-5)