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Evaluation of respiratory Syncytial virus frequency in symptomatic and asymptomatic individuals in a tertiary hospital complex

Grant number: 13/00686-0
Support Opportunities:Regular Research Grants
Start date: June 01, 2013
End date: November 30, 2015
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal Investigator:Nancy Cristina Junqueira Bellei
Grantee:Nancy Cristina Junqueira Bellei
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated researchers: Luciana Peniche Moreira

Abstract

The human respiratory syncytial virus (HRSV) is a major cause of acute respiratory infection in children and infants causing pneumonia and bronchiolitis. Furthermore the virus has a great importance as a causative agent of respiratory infection in immunocompromised having great impact on morbidity and mortality of patients and causing significant economic losses. The HRSV belongs to the family Paramyxoviridae and their genome consists of linear single-stranded RNA of negative polarity. The main routes of transmission are through direct contact or fomites, and its high contagion degree support the occurrence of nosocomial transmission and makes it an important cause of hospital outbreaks during the virus peak periods in the community. Individuals with high exposure and high risk for acquiring the infection, such as healthcare workers, patients with immunosuppression due to HIV infection and individuals who have close contact with HRSV infected children possibly play an important role in the virus chain of transmission, mainly in case of asymptomatic infection, considering that it is possible that the carriers relax on the precautionary measures, since they don't know they are infected but the extension of asymptomatic infection and impact is poorly studied. The study of respiratory syncytial virus infection in asymptomatic individuals is still scarce in the literature both nationally and internationally, so we believe that this study may be of fundamental importance to fill some of the many gaps in understanding the transmission process of this important pathogen. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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