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Application graphite/polurethane and graphite/silicon rubber composite electrodes II

Abstract

In the present research proposal is intended to perform studies with the graphite/poliurethane and graphite/silicon rubber composite electrodes started by our research group some years ago. Now our intention is to use the composites in the determination of substances with pharmacological interest. The pharmaceuticals that will be investigated are captopril, an antihypertensive drug largely used in Brazil and ruthine, a flavonoid with antioxidant and vaso-dilatators properties.For the electroanalytical studies the electrodes will be prepared as mixtures of adequate amounts of graphite and silicon rubber or polyurethane in order to obtain the composition that allows to the better voltammetric response in terms of peak current and mechanical stability. The analytes will be determined in pharmaceutical formulations or in synthetic biologic fluids. The effect of potentially interfering species will also be evaluated And addition recovery tests will be performed and the performance of the proposed methods will be compared with the procedures recommended in the reference literature such as the US Pharmacopea or the Brazilian Pharmacopea.The performance of the graphite polyurethane composites as sensor in flow analysis and as rotating electrodes will also be investigated. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS SANTOS, SIDNEY X.; CAVALHEIRO, EDER T. G. Using of a Graphite-Polyurethane Composite Electrode Modified with a Schiff Base as a Bio-Inspired Sensor in the Dopamine Determination. Journal of the Brazilian Chemical Society, v. 25, n. 6, p. 1071-1077, JUN 2014. Web of Science Citations: 8.
PRISCILA CERVINI; ÉDER TADEU GOMES CAVALHEIRO. Determination of paracetamol at a graphite-polyurethane composite electrode as an amperometric flow detector. Journal of the Brazilian Chemical Society, v. 19, n. 5, p. 836-841, 2008.
I. CESARINO; G. MARINO; J.R. MATOS; E.T.G. CAVALHEIRO. Evaluation of a carbon paste electrode modified with organofunctionalised SBA-15 silica in the determination of copper. Eclética Química, v. 32, n. 2, p. 23-28, 2007.
IVANA CESARINO; GLIMALDO MARINO; JIVALDO DO ROSÁRIO MATOS; ÉDER T. G. CAVALHEIRO. Using the organofunctionalised SBA-15 nanostructured silica as a carbon paste electrode modifier: determination of cadmium ions by differential anodic pulse stripping voltammetry. Journal of the Brazilian Chemical Society, v. 18, n. 4, p. 810-817, 2007.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.