Biomarkers of effects and exposure to aromatic compounds in fish from Santos Bay and adjacent continental self

• Grant number: 05/03801-8
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2006
• End date: August 31, 2008
• Field of knowledge: Physical Sciences and Mathematics - Oceanography
• Principal Investigator: Márcia Caruso Bícego
• Grantee: Márcia Caruso Bícego
• Host Institution: Instituto Oceanográfico (IO). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The clearest ecological meaning of the anthropogenic influence can be seen through the decrease of natural resources and species diversity. At the first level of organization, depending upon concentration and time of exposure, the organisms exposed to pollutants can undergo physiological changes that cause fall in the ratio of growth, decrease of fertility, and rise of mortality. The use of biomarkers to evaluate the exposure to and/or effects of contaminants has received attention in the least 15 years, especially in national environmental monitoring programs in several countries. The polycyclic aromatic compounds (PACs) are the main investigated contaminant in marine environment monitoring studies, due to their potential mutagenic and carcinogenic effects to the organisms. These studies can be carried out through the parental PAC analysis in fish tissue. However, studies have showed that these organisms are capable to metabolizing these compounds quickly, generating hydroxyled and water-soluble compounds. These PAC metabolites are biotransformed in the liver, secreted into the gall bladder, and stored in the bile. Santos Bay, where several intense PAC source activities are situated, is a critical example of environmental degradation. Because of this it is necessary to investigate this region widely, especially concerning interactions between the organisms and the toxic organic compounds from anthropogenic sources. The thematic project called ECOSAN has been evaluating the influence of several aspects of the anthropogenic continental contribution from this area in the ecosystem located at the adjacent continental shelf. This current proposal aims not only at amplifying the investigation carried out by ECOSAN but also at investigating the PAC bioavailability in demersal fish, the toxic effects, and the extension of exposure in Santos Bay and the adjacent continental shelf. This goal will be succeeded through analyses of the biomarkers of exposure (PAC metabolites in bile samples) and effects (lesions in liver tissue) in fish caught in the region. Moreover, biliary protein analysis will be carried out in order to correct differences in feeding status among field samples. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RIZZATTI DE ALBERGARIA-BARBOSA, ANA CECILIA; DA SILVA, DENIS ALBUQUERQUE MOREIRA; DA SILVA ROCHA, ARTHUR JOSE; TANIGUCHI, SATIE; PATIRE, VINICIUS FARIA; DIAS, JUNE FERRAZ; FERNANDEZ, WELLINGTON SILVA; BICEGO, MARCIA CARUSO. Evaluation of polycyclic aromatic hydrocarbons bioavailability on Santos Bay (Brazil) through levels of biliary metabolites. Marine Pollution Bulletin, v. 129, n. 2, p. 822-828, APR 2018. (05/03801-8)

BARRETO, ISANA SOUZA; RIZZATTI DE ALBERGARIA-BARBOSA, ANA CECILIA; PATIRE, VINICIUS FARIAS; SILVA, MARCIO DE JESUS; BALDASSIN, PAULA; TANIGUCHI, SATIE; MONTONE, ROSALINDA CARMELA; GALLO, HUGO; MARANHO, ANDREA; BICEGO, MARCIA CARUSO. Bioavailability of polycyclic aromatic hydrocarbons to penguins on the coast of southeastern Brazil. Marine Pollution Bulletin, v. 157, AUG 2020. (10/07227-2, 05/03801-8, 12/10323-9)

VINICIUS FARIA PATIRE; ANA CECÍLIA RIZZATTI DE ALBERGARIA-BARBOSA; ISANA SOUZA BARRETO; SATIE TANIGUCHI; WELLINGTON SILVA FERNANDEZ; JUNE FERRAZ DIAS; DENIS A. M. DA SILVA; MARCIA CARUSO BÍCEGO. Bioavailability of polycyclic aromatic hydrocarbons in Santos Bay (Brazil) and its adjacent continental shelf. Ocean and Coastal Research, v. 71, 2023-06-09. (05/03801-8, 03/09932-1)