Neuroimmunology, functional genomics and neuroimaging: an integrated approach for studying physiopathology and treatment in refractory epilepsy

• Grant number: 09/53443-1
• Support Opportunities: Research Projects - Thematic Grants
• Start date: December 01, 2010
• End date: November 30, 2015
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Agreement: FAPEMIG
• Principal Investigator: Carlos Alberto Moreira Filho
• Grantee: Carlos Alberto Moreira Filho
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant(s): 12/50722-0 - Factors modulating neural processing time measured using fMRI, AP.R

Abstract

Basic and applied research based on population studies contribute for the identification modifiable risks and, therefore, for developing efficient interventions. Treatments resulting in epilepsy interruption or regression have the potential to be employed as preventive measures. The main objective of this project is to foster a collaborative, research network, encompassing research teams of Minas Gerais and Sao Paulo, with the purpose of investigating clinical, genetic-environmental and neurobiological interactions as factors of risk or protection in epileptogenesis, centered on the association between neuroinflammation and epilepsy of the temporal medial lobe. We aim to investigate neuroinflammatory processes, gene expression and central and peripherical immunological markers in epilepsy patients. Therefore, we will combine multimodal neuroimaging techniques (MRI, PET, CT) and molecular and cellular biology methods in order to identify the mechanisms involved in the physiopathology and the response to treatment in epilepsy. Besides that, we will evaluate if gene polymorphisms linked to relevant anti-epileptic drugs, and neuroinflammatory processes, are associated to pharmacological treatment resistance in epilepsy. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

AZEVEDO, HATYLAS; FUJITA, ANDRE; BANDO, SILVIA YUMI; IAMASHITA, PRISCILA; MOREIRA-FILHO, CARLOS ALBERTO. Transcriptional Network Analysis Reveals that AT1 and AT2 Angiotensin II Receptors Are Both Involved in the Regulation of Genes Essential for Glioma Progression. PLoS One, v. 9, n. 11, NOV 3 2014. (05/56446-0, 11/07762-8, 11/50761-2, 09/53443-1)

AZEVEDO, HATYLAS; RENESTO, PAULO GUILHERME; CHINEN, ROGERIO; NAKA, ERIKA; CARVALHO DE MATOS, ANA CRISTINA; CENEDEZE, MARCOS ANTONIO; MOREIRA-FILHO, CARLOS ALBERTO; SARAIVA CAMARA, NIELS OLSEN; PACHECO-SILVA, ALVARO. Intragraft transcriptional profiling of renal transplant patients with tubular dysfunction reveals mechanisms underlying graft injury and recovery. HUMAN GENOMICS, v. 10, JAN 7 2016. (11/50761-2, 12/02270-2, 09/53443-1)

MOREIRA-FILHO, CARLOS ALBERTO; BANDO, SILVIA YUMI; BERTONHA, FERNANDA BERNARDI; SILVA, FILIPI NASCIMENTO; COSTA, LUCIANO DA FONTOURA; FERREIRA, LEANDRO RODRIGUES; FURLANETTO, GLAUCIO; CHACUR, PAULO; NOGUEIRA ZERBINI, MARIA CLAUDIA; CARNEIRO-SAMPAIO, MAGDA. Modular transcriptional repertoire and MicroRNA target analyses characterize genomic dysregulation in the thymus of Down syndrome infants. ONCOTARGET, v. 7, n. 7, p. 7497-7533, FEB 16 2016. (08/58238-4, 14/50489-9, 05/00587-5, 11/50761-2, 09/53443-1)

BANDO, SILVIA YUMI; SILVA, FILIPI NASCIMENTO; COSTA, LUCIANO DA FONTOURA; SILVA, ALEXANDRE V.; PIMENTEL-SILVA, LUCIANA R.; CASTRO, LUIZ H. M.; WEN, HUNG-TZU; AMARO, JR., EDSON; MOREIRA-FILHO, CARLOS ALBERTO. Complex Network Analysis of CA3 Transcriptome Reveals Pathogenic and Compensatory Pathways in Refractory Temporal Lobe Epilepsy. PLoS One, v. 8, n. 11, NOV 21 2013. (05/56446-0, 05/00587-5, 11/50761-2, 09/53443-1)

MOREIRA-FILHO, CARLOS ALBERTO; BANDO, SILVIA YUMI; BERTONHA, FERNANDA BERNARDI; IAMASHITA, PRISCILA; SILVA, FILIPI NASCIMENTO; COSTA, LUCIANO DA FONTOURA; SILVA, ALEXANDRE VALOTTA; MARTINS CASTRO, LUIZ HENRIQUE; WEN, HUNG-TZU. Community Structure Analysis of Transcriptional Networks Reveals Distinct Molecular Pathways for Early- and Late-Onset Temporal Lobe Epilepsy with Childhood Febrile Seizures. PLoS One, v. 10, n. 5, MAY 26 2015. (05/56446-0, 05/00587-5, 11/50761-2, 09/53443-1)