| Grant number: | 13/07453-0 |
| Support Opportunities: | Regular Research Grants |
| Start date: | August 01, 2013 |
| End date: | January 31, 2016 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Analytical Chemistry |
| Principal Investigator: | Maria de Lourdes Leite de Moraes |
| Grantee: | Maria de Lourdes Leite de Moraes |
| Host Institution: | Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil |
| Associated researchers: | Carolina Vautier Teixeira Giongo ; Daniel Rettori ; Heron Dominguez Torres da Silva ; Lucildes Pita Mercuri |
Abstract
The metabolic profile of a plant extract give us many information about the biologically active compounds presents in the extract. This fingerprint has stimulated integrated approaches able to provide information about the processes of synergy and interactions involved in pharmacological responses of bioactive complex matrices. This project aims to contribute to the knowledge of the chemical composition of tonka bean seeds (Dypterix odorata), through the establishment of the electrophoretic profile (fingerprint) of secondary metabolites presents in polar and nonpolar extracts, the evaluation of the thermal profile of the seed, with quantification of coumarin and evaluate the antioxidant activity of the extracts, trying to identify what / which secondary metabolites are involved in this activity. Cumaru seeds is widely used in Northern for the manufacture of syrups, which are used as antispasmodics; may also be employed pharmacological and cosmetic applications. Despite this, there is no reports about the total composition of secondary metabolites of seed extracts. (AU)
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