| Grant number: | 12/51220-8 |
| Support Opportunities: | Research Grants - Research in Public Policies for the National Health Care System (PP-SUS) |
| Start date: | July 01, 2013 |
| End date: | June 30, 2015 |
| Field of knowledge: | Biological Sciences - Immunology - Applied Immunology |
| Agreement: | CNPq - PPSUS |
| Principal Investigator: | Adele Caterino de Araújo |
| Grantee: | Adele Caterino de Araújo |
| Host Institution: | Instituto Adolfo Lutz (IAL). Coordenadoria de Controle de Doenças (CCD). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil |
Abstract
The aim of the present study is: (i) Establish a surveillance and diagnostic multidisciplinary group of HTLV-1 and HTLV-2 infections at IAL (SuDiHIV/HTLV), firstly analyzing samples from HlV-infected patients attended at the STD/AIDS Reference Center in São Paulo, Brazil (CRT DST/Aids); (ii) compare the efficiency of HTLV-1/2 confirmatory assays in the diagnosis of HIV/HTLV-1/2 coinfected individuals (iii) detect HTLV-1/2 proviral load during ARV therapy, (iv) characterize HTLV and HIV isolates, including HIV tropism, (v) search for unique insertion sites (UIS) and clonallity in HTLV-1/H1V coinfected individuals (in London); (vi) evaluate the number and function of T regulatory cells, and (vii) using bioinformatics and statistical tools, correlate the results obtained with socio-demographic and clinical data. (AU)
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