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Multicomponent organocatalytic strategies to anticancer natural products


This application describes the main objectives, tasks and expected results for the Visiting Professor Project of Prof. Dr. Daniel García Rivera at the Federal University of São Carlos (UFSCar). Dr. Rivera is Associate Professor at the University of Havana (UH) and Head of the Laboratory of Bioorganic Chemistry at the Center for Natural Products Study, Cuba. During the last years, he has served yearly as Visiting Researcher at the Leibniz Institute of Plan Biochemistry, Germany, working on the direction of scientific projects and the supervision of PhD students. He is a leading author in the field of multicomponent reactions (MCRs), steroid chemistry and the synthesis of pseudo-peptide natural products and macrocycles with biological and chemical applications. The proposed four months research and teaching stay at UFSCar aims to set up a multicomponent reaction-based program for the synthesis and screening of natural products and analogues with anticancer activity. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ECHEMENDIA, RADELL; DE LA TORRE, ALEXANDER F.; MONTEIRO, JULIA L.; PILA, MICHEL; CORREA, ARLENE G.; WESTERMANN, BERNHARD; RIVERA, DANIEL G.; PAIXAO, MARCIO W. Highly Stereoselective Synthesis of Natural-Product-Like Hybrids by an Organocatalytic/Multicomponent Reaction Sequence. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v. 54, n. 26, p. 7621-7625, JUN 22 2015. Web of Science Citations: 29.
SCATENA, GABRIEL S.; DE LA TORRE, ALEXANDER F.; CASS, QUEZIA B.; RIVERA, DANIEL G.; PAIXAO, MARCIO W. Multicomponent Approach to Silica-Grafted Peptide Catalysts: A 3D Continuous-Flow Organocatalytic System with On-line Monitoring of Conversion and Stereoselectivity. CHEMCATCHEM, v. 6, n. 11, p. 3208-3214, NOV 2014. Web of Science Citations: 13.

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