Association of receptors for lipid mediators with PRRs in macrophages and dendritic cells

• Grant number: 13/15719-0
• Support Opportunities: Research Projects - Thematic Grants
• Start date: February 01, 2014
• End date: January 31, 2019
• Field of knowledge: Biological Sciences - Immunology
• Principal Investigator: Sônia Jancar
• Grantee: Sônia Jancar
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Ana Paula Lepique ; Carlos Henrique Cardoso Serezani ; Francisco José Oliveira Rios ; Jeffrey Bryant Travers ; Roger Chammas
• Associated research grant(s): 15/50441-9 - Mechanisms mediating anti inflammatory effects of omega 3 fatty acids in metabolic disorders: role of lipid mediators and micro RNAs, AP.R SPRINT
• Associated scholarship(s): 14/21175-6 - Leukotriene B4 in dendritic cells: impact in the immune response in type 1 Diabetes, BP.PD; 14/17852-2 - The PAF receptor-mediated signaling as limiting factor of antitumor chemotherapy: assessment of immune response and the tumor microenvironment, BP.PD; 14/17407-9 - Molecular programs involved in balance of SOCS-1/MyD88 expression in macrophages from individuals with diabetes and consequences in response to infection, BP.PD

Abstract

Macrophages and dendritic cells (DCs) present membrane receptors (PRRs) that recognize microbial structures, Toll-like receptor family being the prototypic receptors of this group. Another group of PRRs recognize altered self components such as oxidized lipids and dying cells and among them the CD36 was the most studied. Stimulation of these receptors induces early generation of lipid mediators (prostanoids, leukotrienes and PAF), cytokine and other genes transcription leading to a given cellular response. Our working hypothesis is that autocrine activation of receptors for lipid mediators in association with the engagement of PRRs, modifies macrophages and DCs phenotype, with important consequences in infection, tumor growth and clearance of dying cells. In the present study we will investigate the effect of: a) PAFR/CD36 association in tumor microenvironmental cells; b) PAFR in tumor-associated immunosuppression and tumor response to chemotherapy and irradiation; c) PAFR/TLR4 association in DCs function and immune responses in vivo; PAFR association with several TLRs on macrophages phenotype and functions; c) LTB4/TLR4 association in macrophages and its effect on the inflammation and resistance to infection in diabetes. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GUIMARAES, JOAO PEDRO TORRES; FILGUEIRAS, LUCIANO RIBEIRO; MARTINS, JOILSON OLIVEIRA; JANCAR, SONIA. Leukotriene Involvement in the Insulin Receptor Pathway and Macrophage Profiles in Muscles from Type 1 Diabetic Mice. Mediators of Inflammation, 2019. (13/15719-0, 17/11540-7)

FILGUEIRAS, LUCIANO RIBEIRO; KOGA, MARIANNA MAINARDI; QUARESMA, PAULA G.; ISHIZUKA, EDSON KIYOTAKA; MONTES, MARLISE B. A.; PRADA, PATRICIA O.; SAAD, MARIO J.; JANCAR, SONIA; RIOS, FRANCISCO J.. PAFR in adipose tissue macrophages is associated with anti-inflammatory phenotype and metabolic homoeostasis. Clinical Science, v. 130, n. 8, p. 601-612, APR 1 2016. (13/15719-0)

CHAMMAS, ROGER; DE SOUSA ANDRADE, LUCIANA NOGUEIRA; JANCAR, SONIA. Oncogenic effects of PAFR ligands produced in tumours upon chemotherapy and radiotherapy. NATURE REVIEWS CANCER, v. 17, n. 4, APR 2017. (13/15719-0, 15/22814-5)

GUIMARAES, JOAO PEDRO TORRES; FILGUEIRAS, LUCIANO RIBEIRO; MARTINS, JOILSON OLIVEIRA; JANCAR, SONIA. Leukotriene Involvement in the Insulin Receptor Pathway and Macrophage Profiles in Muscles from Type 1 Diabetic Mice. Mediators of Inflammation, v. 2019, p. 8-pg., 2019-01-01. (13/15719-0, 17/11540-7)

NEVES, JOSE ANTONIO JANUARIO; DE MATOS, MOZANIA REIS; RAMALHO, THERESA; SANTOS-BEZERRA, DANIELE PEREIRA; CAVALCANTE, CRISTIANE DAS GRACAS DIAS; D'ALPINO PEIXOTO, RENATA; QUEIROZ, MARCIA SILVA; JANCAR, SONIA; CORREA-GIANNELLA, MARIA LUCIA. Increased leukotriene B4 plasma concentration in type 2 diabetes individuals with cardiovascular autonomic neuropathy. DIABETOLOGY & METABOLIC SYNDROME, v. 12, n. 1, NOV 12 2020. (13/15719-0)

ILDEFONSO ALVES DA SILVA JUNIOR; LUCIANA NOGUEIRA DE SOUSA ANDRADE; SONIA JANCAR; ROGER CHAMMAS. Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy. Clinics, v. 73, 2018-10-11. (13/15719-0, 15/22814-5)

DA SILVA JUNIOR, ILDEFONSO ALVES; DE SOUSA ANDRADE, LUCIANA NOGUEIRA; JANCAR, SONIA; CHAMMAS, ROGER. Platelet activating factor receptor antagonists improve the efficacy of experimental chemo- and radiotherapy. Clinics, v. 73, n. 1, 2018. (15/22814-5, 13/15719-0)

SANTOS-BEZERRA, DANIELE P.; FILGUEIRAS, LUCIANO R.; MONTEIRO, MARIA BEATRIZ; ADMONI, SHARON N.; PEREZ, V, RICARDO; CAVALEIRO, ANA M.; MACHADO, CLEIDE G.; MACHADO, UBIRATAN F.; PASSARELLI, MARISA; JANCAR, SONIA; et al. Leukotriene Pathway Activation Associates with Poor Glycemic Control and with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes. Mediators of Inflammation, v. 2020, MAR 23 2020. (16/15603-0, 13/15719-0)