The effect of vitamin D supplementation on bone turnover in fallers postmenopausal women

• Grant number: 14/00001-0
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2014
• End date: March 31, 2016
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Jorge Nahas Neto
• Grantee: Jorge Nahas Neto
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated researchers: Eliana Aguiar Petri Nahás

Abstract

The total bone mass is determined by the balance between bone resorption and bone formation. Bone loss occurs when the balance in bone turnover is changed, resulting in improved resorption of bone. In women, with the onset of menopause, the rate of resorption increases, raising the impact of imbalance in bone turnover. Evidence suggests that rapid bone turnover (measured by biochemical markers of bone resorption and formation) increases bone fragility and risk of osteoporotic fracture. Markers of bone formation and resorption derived from collagen have been used to assess bone loss, providing dynamic assessment of the activity and bone health. Although they cannot be used to diagnose osteoporosis, high levels of these biomarkers have demonstrated to predict incresased rates of bone loss. Vitamin D (VD) is essential for the maintenance of bone mass and calcium absorption. The active form of VD regulates the transcription of a significant number of genes encoding transporter proteins calcium and bone matrix proteins. Research has shown that VD deficiency has negative effects on remodeling and maintaining bone mass. However, most of randomized controlled trials of the effect of supplemental VD on bone mass involving VD associated with supplementation of calcium, making it difficult to separate the effects attributable specifically to isolated VD. The important role played by the related to muscle and bone characteristics VD is under investigation , and their research will allow the early identification of individuals predisposed to sarcopenia, risk of falls and osteoporotic fractures, allowing early intervention in postmenopausal women . It is unclear the isolated effect of VD on bone mass, as well as on markers of bone turnover in postmenopausal women. The hypothesis of this project is that there must be relationship between serum levels of VD, postural balance and bone remodeling, and that supplementation of VD in postmenopausal women with a history of falls, could provide significant reduction in rates of falls, and improvement in bone remodeling and thus in osteoporotic fracture. The results of this project will contribute to a better understanding of the mechanisms involved in bone remodeling and the role of isolated VD. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NAHAS-NETO, J.; CANGUSSU, L. M.; ORSATTI, C. L.; BUELONI-DIAS, F. N.; POLONI, P. F.; SCHMITT, E. B.; NAHAS, E. A. P.. Effect of isolated vitamin D supplementation on bone turnover markers in younger postmenopausal women: a randomized, double-blind, placebo-controlled trial. OSTEOPOROSIS INTERNATIONAL, v. 29, n. 5, p. 1125-1133, MAY 2018. (14/00001-0)