Behavior of strontium ranelate in women over 50 years with upper and lower levels of bone mineral density

• Grant number: 11/21224-9
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2012
• End date: September 30, 2013
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Vivian Marques Miguel Suen
• Grantee: Vivian Marques Miguel Suen
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The Brazilian population has been aging quickly. Old age brings an increase in morbidities such as arthritis, hypertension and others, one of them being osteoporosis. Osteoporosis is characterized by a reduction in mass and altered bone architecture, resulting in increased risk of fractures. Women are more susceptible because they form less bone mass and go through menopause, with sudden drop in estrogen levels, important in maintaining bone structure. Treatment of osteoporosis aims to prevent fractures and reduce morbidity and mortality. In addition to dietary measures and healthy habits, supplementation of calcium and vitamin D, studies have shown the efficacy of strontium in the treatment of osteoporosis, however, there is a dearth of information about the effects of strontium in the human body and its relationship with other nutrients associated bone metabolism, especially in the elderly. This study aims to evaluate the effect of administration of strontium for 2 months, women in lower and upper quartiles of bone mineral density. This effect will be assessed by the determination of strontium plasma, urine and saliva before, the next day and after 2 months of daily administration of 680mg of strontium. (AU)