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Modification of Ti surfaces by Langmuir-Blodgett hybrid films containing biominerals and strontium ranelate to promote the controled Sr2+ release

Grant number: 15/08774-0
Support type:Scholarships in Brazil - Master
Effective date (Start): December 01, 2015
Effective date (End): January 31, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Ana Paula Ramos
Grantee:Marcos Antonio Eufrásio Cruz
Home Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated scholarship(s):16/19677-9 - Sr Ions Influence on Hydroxyapatite Biomineralization using Self-Templated Hierarchical Structures of Collagen-Like Peptide Amphiphiles, BE.EP.MS


Sr2+ has been shown to effectively stimulate bone formation and to inhibit bone resorption in both in vitro and in vivo studies over the last years for osteoporosis treatment. The drug strontium ranelate (SrR) and the strontium substituted calcium phosphates are the main sources used in clinical applications. In this study, Ti surfaces will be modified with hybrid Langmuir-Blodgett (LB) films containing different biominerals and SrR. The interaction between SrR and Langmuir monolayers of different lipid compositions will be studied to choose the better methodology to immobilize the SrR on the Ti surfaces. The main advantage related to the SrR immobilization of the metallic surfaces is the reduction of the collateral effects related to its administration. Moreover, this procedure allows the delivery of the drug direct in the bone injury. Ti surfaces modified with LB films containing Sr2+ and Ca2+ will be exposed to atmosphere saturated with CO2 (g) to promote the growth of SrCO3 e CaCO3. Bioactivity studies and biomimetic growth of hydroxyapatite on the surfaces will be carried out by the exposure to a solution that simulates the pH and ionic composition of the body fluid (SBF). Ti surfaces containing the SrR immobilized in the LB film could be mineralized by the methodology showed previously. The hybrid films will be characterized by their different properties like morphology, roughness, crystallinity and type of mineral, hydrophilicity and surface free energy, and surface charge using different techniques. The ability of the coatings promote controlled release of Sr2+ will be evaluated and classified according to the type of mineral and the presence of SrR. The most promising materials will be tested in vitro by osteoblast viability studies. It is expected at the end of the study the synthesis of new materials for Sr2+ release with optimized physicochemical properties aiming increase the biocompatibility and osteointegration of Ti surfaces.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CRUZ, M. A. E.; SOARES, M. P. R.; PAZIN, W.; ITO, A. S.; FUKADA, S. Y.; CIANCAGLINI, P.; RAMOS, A. P. Interface-driven Sr-morin complexation at Langmuir monolayers for bioactive coating design. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 181, p. 856-863, SEP 1 2019. Web of Science Citations: 0.
CRUZ, M. A. E.; ZANATTA, M. B. T.; DA VEIGA, M. A. M. S.; CIANCAGLINI, P.; RAMOS, A. P. Lipid-mediated growth of SrCO3/CaCO3 hybrid films as bioactive coatings for Ti surfaces. Materials Science & Engineering C-Materials for Biological Applications, v. 99, p. 762-769, JUN 2019. Web of Science Citations: 1.
CRUZ, MARCOS A. E.; TOVANI, CAMILA B.; FAVARIN, BRUNO Z.; SOARES, MARIANA P. R.; FUKADA, SANDRA Y.; CIANCAGLINI, PIETRO; RAMOS, ANA P. Synthesis of Sr-morin complex and its in vitro response: decrease in osteoclast differentiation while sustaining osteoblast mineralization ability. JOURNAL OF MATERIALS CHEMISTRY B, v. 7, n. 5, p. 823-829, FEB 7 2019. Web of Science Citations: 2.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CRUZ, Marcos Antonio Eufrásio. Design of bioinspired materials containing Sr2+ for modification of Ti surfaces. 2018. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto Ribeirão Preto.

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