Investigation on the role of metallodrug-carbohydrate interactions in multidrug resistance tumor cells

• Grant number: 14/09367-7
• Support Opportunities: Research Grants - Visiting Researcher Grant - International
• Start date: August 01, 2014
• End date: October 31, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Ana Maria da Costa Ferreira
• Grantee: Ana Maria da Costa Ferreira
• Visiting researcher: Reglier Marius
• Visiting researcher institution: Aix-Marseille Université (AMU), France
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 11/50318-1 - Development of compounds with pharmacological or medicinal interest and of systems for their transport, detection and recognition in biological media, AP.TEM

Abstract

In these proposed studies, we intend to prepare some dinuclear copper(II) and analogous zinc(II) complexes with imine and/or amine ligands, and characterize the isolated species by different techniques, especially by UV/Vis, IR, EPR, and NMR spectroscopies. Dr. Marius Réglier's group, at Universitè Aix-Marseille, will be mainly responsible for the design and syntheses of specific ligands, that will be used to prepare the corresponding copper(II) and zinc(II) complexes, including mono- and dinuclear species. Our groups have already a previous collaboration on this subject, supported by a COFECUB project (CAPES/USP) that resulted in a Master Degree in 2013 (Cleia Justino Nunes). We intend to verify the activity of this type of metal complexes towards melanoma cells, in particular some lines containing different expressions of galectin-3. In those studies we have the collaboration of Prof. Roger Chammas's group, at Faculty of Medicine, University of São Paulo (FM-USP), and of Dr. Lia S. Nakao, from the Federal University of Paraná (UFPR) who are experts on these kind of cells. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NUNES, CLEIA JUSTIN; BORGES, BEATRIZ ESSENFELDER; NAKAO, LIA SUMIE; PEYROUX, EUGENIE; HARDRE, RENAUD; FAURE, BRUNO; REGLIER, MARIUS; GIORGI, MICHEL; PRIETO, MARCELA BACH; OLIVEIRA, CARLA COLUMBANO; et al. Reactivity of dinuclear copper(II) complexes towards melanoma cells: Correlation with its stability, tyrosinase mimicking and nuclease activity. Journal of Inorganic Biochemistry, v. 149, p. 49-58, AUG 2015. (11/50318-1, 13/07937-8, 14/09367-7)