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Influence of actives / bioactive compounds on physicochemical and in vitro and in vivo functional parameters of lip molded sunscreens

Grant number: 13/18689-5
Support type:Regular Research Grants
Duration: July 01, 2014 - June 30, 2016
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:André Rolim Baby
Grantee:André Rolim Baby
Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Camila Areias de Oliveira ; Daniela D Almeida Peres

Abstract

Considering especially the lips, chronicle exposition to UV radiation does not trigger the same skin defense mechanisms, such as tanning and stratum corneum hypertrophy. Therefore, the use of sunscreen lip balms is extremely important. The Faculty of Pharmaceutical Sciences (University of São Paulo) Cosmetology Group has been developing promising researches and scientific partnerships related to bioactive photoprotection. The group experience demonstrated there is a real necessity in studying complex systems presenting bioactive photoprotection activity, especially the association of UV filters with active natural substances - isolated or in the form of extracts/butters - once non elucidated events occur in the mentioned systems, for example, the increasing or decreasing of Sun Protection Factor (SPF) in the presence of some natural compounds. The aim of this study is the development and physical-chemical and functional evaluation of sunscreen lip balms containing ethylhexyl methoxycinnamate, titanium dioxide and shea butter (Butyrospermum parkii) as the bioactive compound. Specifically, the study purposes are: development of sunscreen lip balms by means of a factorial desing of experiment; physical and physical-chemical characteristics determination; functional properties evaluation by diffuse reflectance spectrophotometry with integrating sphere; and in vivo photoprotective efficacy, obtained by a globally recognized method. Additionally, the present study aims to promote the experimental refinement in Cosmetic Science research and scientific publication, in journals of high impact factor, considering the insertion area of this study and the photoprotection / bioactive photoprotection themes. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SARRUF, FERNANDA D.; SAUCE, RAFAEL; CANDIDO, THALITA M.; OLIVEIRA, CAMILA A.; ROSADO, CATARINA; VELASCO, MARIA V. R.; BABY, ANDRE R. Butyrospermum parkii butter increased the photostability and in vivo SPF of a molded sunscreen system. Journal of Cosmetic Dermatology, MAY 2020. Web of Science Citations: 0.
SARRUF, FERNANDA D.; CANDIDO, THALITA M.; DE OLIVEIRA, CAMILA A.; BOU-CHACRA, NADIA A.; ROBLES VELASCO, MARIA V.; BABY, ANDRE R. Influence of Shea (Butyrospermum parkii) butter, TiO2 and ethylhexyl methoxycinnamate on physical parameters and in vitro photoprotective efficacy. Journal of Cosmetic Dermatology, v. 19, n. 8 DEC 2019. Web of Science Citations: 1.
MAXIMO DANELUTI, ANDRE LUIS; NETO, FRANCISCO MARIANO; RUSCINC, NADIA; LOPES, INGRID; ROBLES VELASCO, MARIA VALERIA; MATOS, JIVALDO DO ROSARIO; BABY, ANDRE ROLIM; KALIA, YOGESHVAR N. Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters. International Journal of Pharmaceutics, v. 570, OCT 30 2019. Web of Science Citations: 0.
ROSADO, CATARINA; TOKUNAGA, VIVIANE KAORI; SAUCE, RAFAEL; DE OLIVEIRA, CAMILA AREIAS; SARRUF, FERNANDA DAUD; PARISE-FILHO, ROBERTO; MAURICIO, ELISABETE; DE ALMEIDA, TENIA SANTOS; ROBLES VELASCO, MARIA VALERIA; BABY, ANDRE ROLIM. Another Reason for Using Caffeine in Dermocosmetics: Sunscreen Adjuvant. FRONTIERS IN PHYSIOLOGY, v. 10, MAY 3 2019. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.