Bladder transitional cell carcinoma: a study of pos-transcriptional modifications and RNA binding proteins

• Grant number: 14/05386-7
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2014
• End date: July 31, 2017
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Principal Investigator: Daisy Maria Favero Salvadori
• Grantee: Daisy Maria Favero Salvadori
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated researchers: Glenda Nicioli da Silva ; Kátia Ramos Moreira Leite ; William de Castro Borges

Abstract

Cancer is characterized as a serious public health problem. Particularly, bladder cancer has a high cost to health system, especially because the necessity of routine clinical monitoring (urine cytology and cystoscopy) and its high recurrence rate. Due to the complexity of biological systems, little is known about the molecular mechanisms responsible for urothelial carcinomas. Literature shows cancer presents a complex network of pathways affecting a large number of cellular processes, such as apoptosis, proliferation, invasion, growth etc. In this context, we highlight RNA-binding proteins (RPBs), post-transcriptional regulators of gene expression which are involved in splicing, polyadenylation, stability, degradation and transport of RNAs and translation. To investigate the impact of RPBs, RNA processing events and gene expression profile in the development of different degrees of bladder tumor, this study proposes to evaluate biopsies from 60 patients with bladder cancer (30 low-grade tumors and 30 high-grade tumors). Ten bladder biopsies from patients with benign prostatic hyperplasia will be used as control. We expect the results might illuminate new mechanisms of tumorigenesis and provide relevant information for the identification of biomarkers for early prognosis and treatment of urothelial carcinomas. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VENTURA SAVIO, A. L.; MOREIRA LEITE, K. R.; BURNS, S.; DA SILVA, G. N.; FAVARETTO GALANTE, P. A.; FERRAZ PENALVA, L. O.; FAVERO SALVADORI, D. M.. Musashi-1 RNA binding protein a new biomarker candidate and therapeutic target in urothelial carcinoma.. Environmental and Molecular Mutagenesis, v. 59, p. 1-pg., 2018-09-01. (14/05386-7, 16/05556-5, 13/23279-0)