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Bladder transitional cell carcinoma: a study of pos-transcriptional modifications and RNA binding proteins

Grant number: 13/23279-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2014
Effective date (End): January 31, 2019
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal researcher:Daisy Maria Favero Salvadori
Grantee:André Luiz Ventura Sávio
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated scholarship(s):16/05556-5 - Functional analysis of 14 RNA binding proteins (RBPs) in two bladder urothelial carcinoma cell lines, BE.EP.DR

Abstract

Cancer is characterized as a serious public health problem. Particularly, bladder cancer has a high cost to health system, especially given the need for routine clinical monitoring (urine cytology and cystoscopy) and high recurrence rate. Due to the complexity of biological systems, little is known about the molecular mechanisms responsible for urothelial carcinomas. The literature shows that in cancer there is involvement of a complex network of pathways affecting a large number of cellular processes such as apoptosis, proliferation, invasion, growth, etc. In this context, we highlight RNA-binding proteins (RPBs), post-transcriptional regulators of gene expression which are involved in splicing, polyadenylation, stability, degradation and transport of RNAs and translation. To investigate the impact of RPBs and RNA processing events in the development of different degrees of bladder tumor, this study proposes to evaluate biopsies from 60 patients with bladder cancer (30 low-grade tumors and 30 high-grade tumors). Ten bladder biopsies from patients with benign prostatic hyperplasia will be used as control. We expect results might illuminate new mechanisms of tumorigenesis and provide information relevant to the identification of biomarkers for early prognosis and treatment of urothelial carcinomas.

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SÁVIO, André Luiz Ventura. Carcinoma urotelial estudo de modificações pós-transcricionais e de proteínas de ligação ao rna. 2019. Doctoral Thesis - Universidade Estadual Paulista "Júlio de Mesquita Filho" Instituto de Biociências (Campus de Botucatu)..

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