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Bladder transitional cell carcinoma: a study of pos-transcriptional modifications and RNA binding proteins

Grant number: 14/05386-7
Support type:Regular Research Grants
Duration: August 01, 2014 - July 31, 2017
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal researcher:Daisy Maria Favero Salvadori
Grantee:Daisy Maria Favero Salvadori
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Assoc. researchers:Glenda Nicioli da Silva ; Kátia Ramos Moreira Leite ; William de Castro Borges

Abstract

Cancer is characterized as a serious public health problem. Particularly, bladder cancer has a high cost to health system, especially because the necessity of routine clinical monitoring (urine cytology and cystoscopy) and its high recurrence rate. Due to the complexity of biological systems, little is known about the molecular mechanisms responsible for urothelial carcinomas. Literature shows cancer presents a complex network of pathways affecting a large number of cellular processes, such as apoptosis, proliferation, invasion, growth etc. In this context, we highlight RNA-binding proteins (RPBs), post-transcriptional regulators of gene expression which are involved in splicing, polyadenylation, stability, degradation and transport of RNAs and translation. To investigate the impact of RPBs, RNA processing events and gene expression profile in the development of different degrees of bladder tumor, this study proposes to evaluate biopsies from 60 patients with bladder cancer (30 low-grade tumors and 30 high-grade tumors). Ten bladder biopsies from patients with benign prostatic hyperplasia will be used as control. We expect the results might illuminate new mechanisms of tumorigenesis and provide relevant information for the identification of biomarkers for early prognosis and treatment of urothelial carcinomas. (AU)