Advanced search
Start date

Phenotypic and genotypic characterization of Candida spp strains of candidemia in universitary hospital

Grant number: 14/10628-0
Support Opportunities:Regular Research Grants
Duration: December 01, 2014 - May 31, 2017
Field of knowledge:Health Sciences - Collective Health - Public Health
Principal Investigator:Márcia Eliana da Silva Ferreira
Grantee:Márcia Eliana da Silva Ferreira
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated researchers:Roberto Martinez


Since the 80s, the number of patients affected by invasive infections caused by Candida species has been increasing due the increase of immunocompromised patients, invasive procedures, and use of broad-spectrum antibiotics. These yeasts, which are part of the human microbiota, take advantage of imbalances on the host to cause infections, which can be superficial or invasive. The invasive infections, known as candidemia, can present a mortality rate up to 50% and they are mainly caused by Candida albicans, C. parapsilosis, C. glabrata and C. tropicalis. Their prevalence varies between countries and each species has special characteristics, which makes necessary their identification. In addition to the identification, characterization of isolates in epidemiological studies is relevant and can be done using the antifungal susceptibility tests and phenotypic and genotypic tests. In this context, this project purposes to characterize, phenotypically and genotypically, isolates from candidemia episodes occurred on clinics hospital of FMRP, as well as analyze their susceptibility to the antifungal agents used in the treatment of candidemia. For this, tests will be done to detect the presence of proteinase, phospholipase and hemolysin; biofilm formation ability; MLST, PFGE and MLP genotyping; and disk diffusion susceptibility method and broth microdilution method according to CLSI guidelines. It is expected; therefore, contribute to this disease epidemiology on the hospital and in Brazil. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CANELA, HELIARA MARIA SPINA; CARDOSO, BARBARA; FRAZAO, MILIANE RODRIGUES; FALCAO, JULIANA PFRIMER; VITALI, LUCIA HELENA; MARTINEZ, ROBERTO; DA SILVA FERREIRA, MARCIA ELIANA. Genetic diversity assessed using PFGE, MLP and MLST in Candida spp. candidemia isolates obtained from a Brazilian hospital. Brazilian Journal of Microbiology, v. 52, n. 2, . (14/10628-0, 13/23485-0)
SPINA CANELA, HELIARA MARIA; CARDOSO, BARBARA; VITALI, LUCIA HELENA; COELHO, HARNOLDO COLARES; MARTINEZ, ROBERTO; FERREIRA, MARCIA ELIANA DA SILVA. Prevalence, virulence factors and antifungal susceptibility of Candida spp. isolated from bloodstream infections in a tertiary care hospital in Brazil. MYCOSES, v. 61, n. 1, p. 11-21, . (13/23485-0, 14/10628-0)
BRANCINI, GUILHERME T. P.; BACHMANN, LUCIANO; FERREIRA, MARCIA ELIANA DA S.; RANGEL, DRAUZIO E. N.; BRAGA, GILBERTO U. L.. Exposing Metarhizium acridum mycelium to visible light up-regulates a photolyase gene and increases photoreactivating ability. Journal of Invertebrate Pathology, v. 152, p. 35-37, . (15/24305-0, 14/10628-0, 16/11386-5, 13/50518-6, 10/06374-1)

Please report errors in scientific publications list by writing to: