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Involvement of Von Willebrand factor in hemostatic disturbances induced by Bothrops jararaca snake venom: experimental study

Grant number: 13/25177-0
Support type:Regular Research Grants
Duration: January 01, 2015 - December 31, 2017
Field of knowledge:Biological Sciences - Pharmacology
Principal Investigator:Marcelo Larami Santoro
Grantee:Marcelo Larami Santoro
Home Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo, SP, Brazil
Assoc. researchers:José Ricardo Jensen ; Katia Cristina Barbaro Nogueira ; Vania Gomes de Moura Mattaraia
Associated grant(s):16/50411-5 - Isolation and characterization of Brothrops jararaca snake venom proteins that induce thrombocytopenia , AP.R


Bothrops jararaca snake venom disrupts various biological systems in a complex and dynamic manner, causing thereby the rapid death of natural preys. Among these biological systems, the hemostatic system is a crucial target for snake venoms; particularly, B. jararaca venom has various pro- and anti-hemostatic activities. Given the wide range of hemostatic activities found in this venom, bleeding disorders occurring in patients are multifactorial. However, it is intriguing that some important features of hemorrhagic manifestations presented by patients bitten by B. jararaca, e.g. gingival bleeding, epistaxis, petechiae and suffusions, resemble those observed in patients with von Willebrand disease. Likewise, although the venom induces thrombocytopenia in envenomed patients, it is unknown whether von Willebrand factor (vWF) is involved in such process. Thus, this project aims: (1) to analyze the occurrence of quantitative and qualitative changes of vWF and its cleavage enzyme, ADAMTS13, during experimental envenomation by B. jararaca; (2) to investigate the role of vWF in the development of venom-induced thrombocytopenia. (AU)

Articles published in Agência FAPESP about the research grant
Substance found in fruit helps combat the effects of jararaca viper venom 

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AZEVEDO SACHETTO, ANA TERESA; ROSA, JAQUELINE GOMES; SANTORO, MARCELO LARAMI. Rutin (quercetin-3-rutinoside) modulates the hemostatic disturbances and redox imbalance induced by Bothrops jararaca snake venom in mice. PLoS Neglected Tropical Diseases, v. 12, n. 10 OCT 2018. Web of Science Citations: 1.
AGUSTINA QUINTANA, MARIA; SCIANI, JULIANA MOZER; VATTI AUADA, ALINE VIVIAN; MERCEDES MARTINEZ, MARIA; NICOLAS SANCHEZ, MAGAS; SANTORO, MARCELO LARAMI; FAN, HUI WEN; ELISA PEICHOTO, MARIA. Stinging caterpillars from the genera Podalia, Leucanella and Lonomia in Misiones, Argentina: A preliminary comparative approach to understand their toxicity. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, v. 202, p. 55-62, NOV 2017. Web of Science Citations: 3.
RODRIGUES, MARIANA VALOTTA; DE CASTRO, SIMONE OLIVEIRA; DE ALBUQUERQUE, CYNTHIA ZACCANINI; DE MOURA MATTARAIA, VANIA GOMES; SANTORO, MARCELO LARAMI. The gingival vein as a minimally traumatic site for multiple blood sampling in guinea pigs and hamsters. PLoS One, v. 12, n. 5 MAY 22 2017. Web of Science Citations: 0.
ELISA PEICHOTO, MARIA; SANTORO, MARCELO LARAMI. Patagonfibrase modifies protein expression of tissue factor and protein disulfide isomerase in rat skin. Toxicon, v. 119, p. 330-335, SEP 1 2016. Web of Science Citations: 4.
SANTORO, MARCELO LARAMI; DO CARMO, THAIS; LOPES CUNHA, BRUNA HELOISA; ALVES, ANDRE FONSECA; ZELANIS, ANDRE; DE TOLEDO SERRANO, SOLANGE MARIA; GREGO, KATHLEEN FERNANDES; SANT'ANNA, SAVIO STEFANINI; BARBARO, KATIA CRISTINA; FERNANDES, WILSON. Ontogenetic Variation in Biological Activities of Venoms from Hybrids between Bothrops erythromelas and Bothrops neuwiedi Snakes. PLoS One, v. 10, n. 12 DEC 29 2015. Web of Science Citations: 5.

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