Disturbances of Von Willebrand factor and hepatic synthesis of hemosthatic factors...
| Grant number: | 13/25177-0 |
| Support type: | Regular Research Grants |
| Duration: | January 01, 2015 - December 31, 2017 |
| Field of knowledge: | Biological Sciences - Pharmacology |
| Principal Investigator: | Marcelo Larami Santoro |
| Grantee: | Marcelo Larami Santoro |
| Home Institution: | Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo, SP, Brazil |
| Assoc. researchers: | José Ricardo Jensen ; Katia Cristina Barbaro Nogueira ; Vania Gomes de Moura Mattaraia |
| Associated grant(s): | 16/50411-5 - Isolation and characterization of Brothrops jararaca snake venom proteins that induce thrombocytopenia , AP.R |
Abstract
Bothrops jararaca snake venom disrupts various biological systems in a complex and dynamic manner, causing thereby the rapid death of natural preys. Among these biological systems, the hemostatic system is a crucial target for snake venoms; particularly, B. jararaca venom has various pro- and anti-hemostatic activities. Given the wide range of hemostatic activities found in this venom, bleeding disorders occurring in patients are multifactorial. However, it is intriguing that some important features of hemorrhagic manifestations presented by patients bitten by B. jararaca, e.g. gingival bleeding, epistaxis, petechiae and suffusions, resemble those observed in patients with von Willebrand disease. Likewise, although the venom induces thrombocytopenia in envenomed patients, it is unknown whether von Willebrand factor (vWF) is involved in such process. Thus, this project aims: (1) to analyze the occurrence of quantitative and qualitative changes of vWF and its cleavage enzyme, ADAMTS13, during experimental envenomation by B. jararaca; (2) to investigate the role of vWF in the development of venom-induced thrombocytopenia. (AU)
| Articles published in Agência FAPESP about the research grant |
| Substance found in fruit helps combat the effects of jararaca viper venom |