Correlation between topographic distribution of aortic valve calcium and hemodynamic repercussion in degenerative aortic stenosis

• Grant number: 13/17933-0
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2014
• End date: November 30, 2016
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Flávio Tarasoutchi
• Grantee: Flávio Tarasoutchi
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Antonio Sergio de Santis Andrade Lopes ; Cesar Higa Nomura ; Marcelo Luiz Campos Vieira ; Max Grinberg

Abstract

The intensity of calcification constitutes the main determinant of the onset of symptoms in degenerative aortic stenosis (DAS). Although there is significant amount of studies evaluating the degree of aortic valve calcification as a predictor of clinical events in DAS, there are no studies assessing the impact of topographic distribution of calcification in the hemodynamic consequences. Objectives: this study pretends to evaluate the hemodynamic impact of the topographic distribution of valve calcification in patients with moderate to severe DAS; determine distribution patterns of calcification according to the severity of the disease; evaluate the correlation between coronary and aortic valve calcium scores. Methods: This is a cross-sectional single-center study, with a sample of 100 patients (50 with moderate DAS and 50 with DAS). All patients should undergo three-dimensional transthoracic echocardiography (to obtain the haemodynamic parameters, degree of calcification and valve area), laboratorial evaluation and helicoidal computed tomography (CT-scan) of the chest with determination of the coronary and aortic valve calcium scores. The topography of the calcification should be determined by unenhanced helicoidal computed tomography, with categorization into 2 groups: predominantly commissural calcification (CC) and predominantly non-commissural calcification (NCC). Through subsequent analysis of the results, we should verify possible hemodynamic differences and peculiarities related to calcium distribution in DAS. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE SANTIS, ANTONIO; TARASOUTCHI, FLAVIO; ARAUJO FILHO, JOSE DE ARIMATEIA B.; VIEIRA, MARCELO C.; NOMURA, CESAR H.; KATZ, MARCELO; SPINA, GUILHERME S.; SAMPAIO, RONEY O.; ACCORSI, TARSO A. D.; ROSA, VITOR E. E.; et al. Topographic Pattern of Valve Calcification A New Determinant of Disease Severity in Aortic Valve Stenosis. JACC-CARDIOVASCULAR IMAGING, v. 11, n. 7, p. 1032-1035, JUL 2018. (13/17933-0)

DE SANTIS, A.; TARASOUTCHI, F. T.; ARAUJO FILHO, J. A. B.; KATZ, M.; VIEIRA, M. C.; NOMURA, C. H.; SPINA, G. S.; SAMPAIO, R. O.; BROWN, J.; EDELMAN, E. R.; et al. Topographic pattern of valve calcification: a new determinant of disease severity in aortic valve stenosis. EUROPEAN HEART JOURNAL, v. 38, p. 1-pg., 2017-08-01. (13/17933-0)