Identification of molecular markers for the development of novel therapeutic agents with angiogenic properties

• Grant number: 14/21177-9
• Support Opportunities: Regular Research Grants
• Start date: February 01, 2015
• End date: April 30, 2017
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Ricardo Jose Giordano
• Grantee: Ricardo Jose Giordano
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Diana Noronha Nunes ; Dirce Maria Carraro ; Emmanuel Dias-Neto ; João Carlos Setubal

Abstract

Angiogenesis is the formation of new blood vessels from pre-existing ones and it is an important process in health and disease. Examples in which angiogenesis participate in disease are cancer and retinopathy, a important cause for blindness in adults. Retinopathy of prematurity or in diabetes, as well as macula degeneration have an important angiogenic component. These diseases afflict people of all ages, classes and races, and have an important impact on Brazilian population because many of individuals affected by these disease are in their most productive period. Drugs that prevent angiogenesis have shown promising results for the treatment of cancer and retinopathies. In this new project, we propose to extend studies from our laboratory on receptor tyrosine kinases involved in angiogenesis and focus on the orphan receptor from the Tie family. And in a new line of study, determine the transcriptome of the angiogenic retina to identify new targets for drug development using our combinatorial peptide libraries. In summary, we hope to identify a new ligand for an important angiogenic receptor (Tie1) and by genomic approaches, increase our knowledge on number of molecular targets for the development of novel therapeutic approaches for diseases with an angiogenic component. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

REIS TEIXEIRA, ANDRE AZEVEDO; CARNERO, LUIS RODRIGUEZ; KURAMOTO, ANDREIA; TANG, FENNY HUI FEN; GOMES, CARLOS HERNIQUE; PEREIRA, NATALIA BUENO; DE OLIVEIRA, LEA CAMPOS; GARRINI, REGINA; MONTEIRO, JHONATAS SIRINO; SETUBAL, JOAO CARLOS; et al. A refined genome phage display methodology delineates the human antibody response in patients with Chagas disease. ISCIENCE, v. 24, n. 6, JUN 25 2021. (14/21177-9)

CARNERO, LUIS ANTONIO RODRIGUEZ; REIS, ANDREAZEVEDO; TANG, FENNY HUI FEN; KURAMOTO, ANDREIA; PASQUALINI, RENATA; ARAP, WADIH; SETUBAL, JOAO CARLOS; CUNHA-NETO, EDECIO; JOSEGIORDANO, RICARDO; ALVES, MARIA JULIA MANSO; et al. Protocol for design, construction, and selection of genome phage (gPhage) display libraries. STAR PROTOCOLS, v. 2, n. 4, p. 24-pg., 2021-12-17. (14/21177-9)