Influence of genetic polymorphisms in the patterns of bacterial colonization and recolonization in chornic periodontitis patients

• Grant number: 14/17886-4
• Support Opportunities: Regular Research Grants
• Duration: March 01, 2015 - February 28, 2017
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Gustavo Pompermaier Garlet
• Grantee: Gustavo Pompermaier Garlet
• Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
• Associated researchers: Magda Feres Figueiredo

Abstract

Chronic periodontitis is a complex disease involving the interaction between infecting microorganisms and the host´s immune/inflammatory response. Genetic factors can modulate the host´s ability to cope with the bacterial challenge tipping the balance towards a resistant or susceptible phenotype, characterized by the occurrence and extent of irreversible tooth attachment loss. Nevertheless, genetic research investigating susceptibility traits in candidate genes related to immune response had been contradictory and inconclusive. On the other hand, recent genome wide association studies had identified a series of single nucleotide polymorphisms related to increased risk of suffering subgingival infection from putative periodontal pathogens, providing a link between the infection pattern and host´s susceptibility to disease. Therefore, we propose to investigate the influence of the SNP associated to periodonto-pathogenic infection with the subgingival colonization pattern, clinical disease parameters and immune/inflammatory markers in a sample population of subjects characterized as resistant to chronic periodontitis, susceptible to the disease, and controls; in both cross-sectional and prospective cohorts. This approach will provide further insight into the interlinked mechanisms of disease pathogenesis and could contribute to the development of new and more efficient therapeutic strategies. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

COLAVITE, PRISCILA MARIA; CAVALLA, FRANCO; GARLET, THIAGO POMPERMAIER; SORIANI AZEVEDO, MICHELLE DE CAMPOS; MELCHIADES, JESSICA LIMA; CAMPANELLI, ANA PAULA; LETRA, ARIADNE; FAVARO TROMBONE, ANA PAULA; SILVA, RENATO MENEZES; GARLET, GUSTAVO POMPERMAIER. TBX21-1993T/C polymorphism association with Th1 and Th17 response at periapex and with periapical lesions development risk. Journal of Leukocyte Biology, v. 105, n. 3, p. 609-619, MAR 2019. (14/03276-0, 15/18163-9, 15/24637-3, 14/17886-4)

CAVALLA, FRANCO; BIGUETTI, CLAUDIA C.; DIONISIO, THIAGO J.; AZEVEDO, MICHELLE C. S.; MARTINS, JR., WALTER; SANTOS, CARLOS F.; TROMBONE, ANA PAULA F.; SILVA, RENATO M.; LETRA, ARIADNE; GARLET, GUSTAVO P.. CCR5 Delta 32 (rs333) polymorphism is associated with decreased risk of chronic and aggressive periodontitis: A case-control analysis based in disease resistance and susceptibility phenotypes. CYTOKINE, v. 103, p. 142-149, MAR 2018. (14/03276-0, 14/17886-4)