Validation of dengue case definitions in children and adolescents from Araraquara, an endemic City of São Paulo

• Grant number: 14/21527-0
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2015
• End date: October 31, 2017
• Field of knowledge: Health Sciences - Collective Health - Epidemiology
• Principal Investigator: Fredi Alexander Diaz Quijano
• Grantee: Fredi Alexander Diaz Quijano
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Claudio Sergio Pannuti ; Eliseu Alves Waldman ; Expedito José de Albuquerque Luna ; Gerusa Maria Figueiredo

Abstract

Objectives: To validate definitions of suspected and probable dengue, based on a score of clinical diagnosis, and compare them with the definitions given by the World Health Organization (WHO). Methodology: This is a study of evaluation of diagnostic technology, nested in a population-based cohort of 3,400 children and adolescents (2-16 years old) living in Araraquara, a dengue endemic city. This cohort will be followed for a period of three years for the detection of new cases of acute febrile illness, which will be investigated with specific test for diagnosis of dengue. This project will study a prospective cohort of patients with acute febrile illness of unknown origin (SFA-OD), derived from earlier, in the period 2015 to 2016. In this group (n = 364), which include both cases of dengue as other causes of SFA-OD, will estimate the validity of different case definitions of dengue, including those established by the WHO and a proposal based on a prior study conducted in another population. Results of serological and virological tests will considered as the gold standard. These tests include IgM, NS1 antigen and real-time PCR. Analysis: The sensitivity and specificity of case definitions will be estimated and compared using the exact McNemar test for paired proportions. Subsequently, based on these results will be proposed diagnostic algorithms integrating clinical and laboratory criteria to optimize the tools available in endemic areas. Expected results: It is expected to obtain a measure of the validity of case definitions. Thus, we intend to present criteria to determine which tools to use in dengue surveillance, in estimating the burden of disease and in the evaluation of public health interventions. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DIAZ-QUIJANO, FREDI A.; FIGUEIREDO, GERUSA M.; WALDMAN, ELISEU A.; FIGUEIREDO, WALTER M.; CARDOSO, MARIA R. A.; CAMPOS, SERGIO R. C.; COSTA, ANGELA A.; PANNUTI, CLAUDIO S.; LUNA, EXPEDITO J. A.. Comparison of clinical tools for dengue diagnosis in a pediatric population-based cohort. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 113, n. 4, p. 212-220, APR 2019. (14/21527-0)