Development of new GPCRs interacting drugs to treatment of inflammatory diseases

• Grant number: 14/50831-9
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2015
• End date: June 30, 2017
• Field of knowledge: Biological Sciences - Pharmacology
• Agreement: CONFAP ; Newton Fund, with FAPESP as a partner institution in Brazil ; MRC, UKRI
• Principal Investigator: Fernando de Queiroz Cunha
• Grantee: Fernando de Queiroz Cunha
• Principal researcher abroad: Stephen John Hill
• Institution abroad: University of Nottingham, University Park, England
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated scholarship(s): 15/13672-2 - Development of new GPCRs interacting drugs to treatment of inflammatory diseases, BP.TT

Abstract

Inflammatory diseases are a complex and heterogeneous group of diseases that affect more than 10% of the word population. The current options for the treatment of these diseases are still limited and in some cases, inefficient due to in understanding of the mechanisms underlying these diseases. In this context, the aim of the present is to create an international collaborative consortium between the Center for Research in Inflammatory Diseases (CRIO) located at Ribeirão Preto Medical School (FMRP) and School of Pharmacy of Ribeiro Preto (FCFRP), University of São Paulo (USP), and University of Nottingham (UoN). The overarching objective is to build capacities to promote knowledge transfer and offer relevant training for graduate students from the Partner Institutions, in order to establish a framework for an integrative research in drug discovery. In this context, our goals will be to identify: 1) To establish an intercontinental collaborative consortium between the University of Nottingham and the University of Sao Paulo for the study of G protein-coupled receptors relevant to inflammatory disease; 2) To conduct an initial pilot study to develop biased agonists for the beta1-adrenoceptor and evaluate their potential as inotropic agents for the treatment of septic shock following acute infection; 3)To establish a knowledge transfer partnership to enhance bidirectional transfer of knowledge and training among scientists, postdoctoral fellows and graduate students from the Universities of Nottingham and São Paulo. (AU)