Ikaros: role in the BCR- signaling in B-1 cells and association with chronic lymphocytic leukemia

• Grant number: 15/01986-2
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2015
• End date: August 31, 2017
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Ana Flavia Popi
• Grantee: Ana Flavia Popi
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Ikaros is considered an important regulator of lymphoid development and differentiation. Several reports reinforce the hypothesis that Ikaros expression is deregulated in human leukemias. It has been suggest the role of Ikaros in the regulation of the transcription of genes that are involved in the BCR signaling. The absence of Ikaros is in detrimental for activation of BCR signals. The Ikaros activity is regulated by kinases and phosphorilases, such as Btk. It is known that Btk deficiency reduced the number of B-1 cells. Additionally, some authors have demonstrated that BCR engagement in B-1 cells results in low proliferation rate and apoptosis induction, opposite to observed in B-2 lymphocytes. Interestingly, the absence of BCR signals diminish B-1 cell population, otherwise the over activation of this pathway is related to proliferative disorders. Despite of several reports demonstrated that some BCR signaling components are differentially expressed in B-1 and B-2 lymphocytes, a clear explanation about how this signaling pathway is regulated has not emerged yet. Considering this, herein we purpose to investigate the role of Ikaros in the regulation of BCR signaling, aiming to clarify some aspects about the participation of B-1 cells in the leukemia. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GUIRNARAES-CUNHA, CAROLINE FERREIRA; ALVARES-SARAIVA, ANUSKA MARCELINO; APOSTOLICO, JULIANA DE SOUZA; POPI, ANA FLAVIA. Radiation-resistant B-1 cells: A possible initiating cells of neoplastic transformation. Immunobiology, v. 221, n. 7, p. 845-852, JUL 2016. (15/01986-2)

DE OLIVEIRA, VIVIAN CRISTINA; DE LACERDA, MARCELO PITOMBEIRA; MUNIZ MORAES, BARBARA BOMFIM; GOMES, CAIO PEREZ; MARICATO, JULIANA TERZI; SOUZA, OLIVIA FONSECA; SCHENKMAN, SERGIO; PESQUERO, JOAO BOSCO; MORETTI, NILMAR SILVIO; RODRIGUES, CELSO ARRAIS; et al. Deregulation of Ikaros expression in B-1 cells: New insights in the malignant transformation to chronic lymphocytic leukemia. Journal of Leukocyte Biology, v. 106, n. 3, SI, p. 581-594, SEP 2019. (11/51973-3, 15/01986-2, 14/27198-8)

DE OLIVEIRA, VIVIAN CRISTINA; PIRES SODRE, ANA CLARA; GOMES, CAIO PEREZ; MORETTI, NILMAR SILVIO; PESQUERO, JOAO BOSCO; POPI, ANA FLAVIA. Alteration in Ikaros expression promotes B-1 cell differentiation into phagocytes. Immunobiology, v. 223, n. 2, p. 252-257, FEB 2018. (15/01986-2)

POPI, ANA F.; LONGO-MAUGERI, IEDA M.; MARIANO, MARIO. An Overview of B-1 Cells as Antigen-Presenting Cells. FRONTIERS IN IMMUNOLOGY, v. 7, APR 11 2016. (15/01986-2)