| Grant number: | 15/01753-8 |
| Support Opportunities: | Regular Research Grants |
| Start date: | July 01, 2015 |
| End date: | June 30, 2017 |
| Field of knowledge: | Biological Sciences - Botany |
| Principal Investigator: | Luciana Francisco Fleuri |
| Grantee: | Luciana Francisco Fleuri |
| Host Institution: | Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
| Associated researchers: | Willian Fernando Zambuzzi |
Abstract
The agroindustrial residues are considered a world-wide problem and they can be used as substrates for solid state fermentation (SSF) processes aiming the achievement of fungal lipases (indirectly), or they can be the sources of such enzymes (direct form). The lipases are capable of catalyzing the hydrolysis of glycerides, as well as several synthesis reactions in micro-aqueous conditions. However, its use is still limited, mainly due to high cost of these enzymes, which are market for high values and the small number of industries that hold this technology. So lipases produced by indirectly or directly from these residues may contribute to lower the production cost of these biocatalysts allowing different applications. In addition, the products of lipases hydrolysis and synthesis may also show activities such as antioxidant, antimicrobial and antitumor, which expand its use. In the light of these statements, fungi will be used for SSF for lipase production using new residues (dried distillers grains with solubles and waste residues from the orange process), followed by optimization of the fermentation conditions. The most promising enzymes (fungal and vegetable) will be characterized as for specificity to fatty acids of different sizes of carbon chain and regionselectivity. Then, lipases will be up scale produced/obtained, concentrated and applied in hydrolysis reactions aiming the bioremediation; esterification and alcoholysis for biodiesel production and interesterification for modification of oils and fats. The products of these reactions will also be tested for several biological activities, which will be correlated with chemical structure and / or components responsible for these activities. (AU)
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