Chemical diversity and biological potential of selected species of São Paulo's flora

• Grant number: 14/15299-4
• Support Opportunities: Regular Research Grants
• Start date: July 01, 2015
• End date: June 30, 2017
• Field of knowledge: Biological Sciences - Botany - Applied Botany
• Principal Investigator: Maria Claudia Marx Young
• Grantee: Maria Claudia Marx Young
• Host Institution: Instituto de Botânica. São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Associated researchers: Inês Cordeiro ; Ivana Barbosa Suffredini ; Luce Maria Brandão Torres ; Paulo Roberto Hrihorowitsch Moreno

Abstract

The Plant kingdom is responsible for the most part of the registered literature on chemical diversity, represented by natural products with complex structures, and with several biological activities, giving them a commercial interest as medicines, flavorings, fragrances and pesticides that play a relevant role in the worldwide economy. The Brazilian tropical flora may be considered one of the richest and less explored sources of substrates used in the search for new molecular models that may, by chemical and pharmacological studies, lead to the discover of new medicines for the cure or control of different diseases. In this context, within one of the aims of the institutional project "Conservation and sustainable utilization of Cerrado and Atlantic Forest: chemical diversity and investigation of the biological potential of secondary metabolites", our group has been working in the bioprospection of native plants that posses biological activities, among these Conchocarpus fontanesianus (Rutaceae), Avicennia schaueriana (Acanthaceae) and Hedyosmum brasiliense (Chloranthaceae) were selected due to the anticholinesterase, antimicrobial, antifungal and antioxidant activities previously detected. The aim of this project is to increase the knowledge about the chemical diversity from native species, as well as to aggregate a value to these species through the discovery of new active compounds with potential application in the development of new medicines for the activities studied. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MURAKAMI, CYNTHIA; CABRAL, RODRIGO SANT'ANA; GOMES, KAIO S.; COSTA-SILVA, THAIS A.; AMARAL, MAIARA; ROMANELLI, MAIARA; TEMPONE, ANDRE G.; LAGO, JOAO HENRIQUE G.; BOLZANI, VANDERLAN DA S.; MORENO, PAULO ROBERTO H.; et al. Hedyosulide, a novel trypanosomicidal sesterterpene lactone from Hedyosmum brasiliense Mart. ex Miq. PHYTOCHEMISTRY LETTERS, v. 33, p. 6-11, OCT 2019. (14/17561-8, 14/15299-4)

CABRAL, RODRIGO S.; SUFFREDINI, IVANA B.; YOUNG, MARIA C. M.. Chemical Composition and invitro Biological Activities of Essential Oils from Conchocarpusfontanesianus (A. St.-Hil.) Kallunki & Pirani (Rutaceae). CHEMISTRY & BIODIVERSITY, v. 13, n. 10, p. 1273-1280, OCT 2016. (11/12515-0, 14/15299-4)