Association of the Functional MICA-129 Polymorphism With the Severity of Chronic Chagas Heart Disease

• Grant number: 15/15163-8
• Support Opportunities: Regular Research Grants - Publications - Scientific article
• Start date: September 01, 2015
• End date: February 29, 2016
• Field of knowledge: Biological Sciences - Immunology - Immunogenetics
• Principal Investigator: Cinara de Cássia Brandão
• Grantee: Cinara de Cássia Brandão
• Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil

Abstract

MICA-129 polymorphism affects the binding affinity of MICA molecules with the NKG2D receptor and influences effector cell function. The genotype met/met was associated with the severity of left ventricular systolic dysfunction(LVSD) in patients with chronic Chagas heart disease, while the val/val genotype was associated with the absence of LVSD. (AU)