New therapeutic perspectives in obesity

• Grant number: 13/08522-6
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2015
• End date: August 31, 2017
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Ana Raimunda Dâmaso
• Grantee: Ana Raimunda Dâmaso
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Obesity is a chronic disease of increasing prevalence, being currently considered a global epidemic, including children, adolescents, adults and the elderly of different nationalities and ethnicities, socioeconomic levels, education levels. Non-pharmacological therapeutic interventions, such as physical exercise and fitness healthy eating strategies, seem to be increasingly studied and recommended for healthy weight loss. In addition, therapies that can complement the effect of exercise and diet for reducing body weight are considerate important strategies. Thus, experimental evidence shows that the use of laser therapy combined with exercise swimming was effective in controlling the lipid profile, reducing the mass of adipose tissue, suggesting increased metabolic activity and changes in lipid metabolism. Objective: To investigate the effect of the use therapeutic laser associated with combined exercise on the responses of adipose tissue transdifferentiation in obese women undergoing weight loss therapy. Methodology: The study population will consist of individuals aged 20-40 years with a body mass index (BMI) e 30 kg/m² of both genders, obese primary, which will be divided into 3 groups of interventions. Body composition, blood collection and clinical, nutritional and lifestyle will be evaluated. The study protocol will consist of physical exercise sessions and concurrent application of phototherapy. (AU)

Scientific publications

(15)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ANA CLAUDIA PELISSARI KRAVCHYCHYN; RAQUEL MUNHOZ DA SILVEIRA CAMPOS; YASMIN ALABY MARTINS FERREIRA; SOFIA EMANUELLE DE CASTRO FERREIRA VICENTE; FLÁVIA CAMPOS CORGOSINHO; LILA MISSAE OYAMA; VALTER TADEU BOLDARINE; LIAN TOCK; DAVID THIVEL; ANA RAIMUNDA DÂMASO. O Papel dos Níveis Séricos de ANP na Perda de Peso, Risco Cardiometabólico e Composição Corporal de Adolescentes com Obesidade Submetidos a Terapia Interdisciplinar. Arquivos Brasileiros de Cardiologia, v. 118, n. 1, p. 33-40, 2022-02-21. (15/14309-9, 11/50414-0, 13/08522-6)

PELISSARI KRAVCHYCHYN, ANA CLAUDIA; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; CORGOSINHO, FLAVIA CAMPOS; LANDI MASQUIO, DEBORAH CRISTINA; DE CASTRO FERREIRA VICENTE, SOFIA EMANUELLE; MARTINS FERREIRA, YASMIN ALABY; SILVA, PATRICIA LEAO; GANEN, ALINE DE PIANO; OYAMA, LILA MISSAE; TOCK, LIAN; et al. The Long-Term Impact of High Levels of Alpha-Melanocyte-Stimulating Hormone in Energy Balance Among Obese Adolescents. ANNALS OF NUTRITION AND METABOLISM, v. 72, n. 4, p. 279-286, 2018. (17/07372-1, 13/19046-0, 13/08522-6)

DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; DAMASO, ANA RAIMUNDA; LANDI MASQUIO, DEBORAH CRISTINA; DUARTE, FERNANDA OLIVEIRA; SENE-FIORESE, MARCELA; AQUINO, JR., ANTONIO EDUARDO; SAVIOLI, FILIPPO ARAGAO; LOPES QUINTILIANO, PAMELA CRISTINA; PELISSARI KRAVCHYCHYN, ANA CLAUDIA; GUIMARAES, LILIANE ISABEL; et al. The effects of exercise training associated with low-level laser therapy on biomarkers of adipose tissue transdifferentiation in obese women. Lasers in Medical Science, v. 33, n. 6, p. 1245-1254, AUG 2018. (13/19046-0, 15/14309-9, 13/08522-6)

DA SILVEIRA CAMPOS, RAQUEL M.; LANDI MASQUIO, DEBORAH C.; CORGOSINHO, FLVIA CAMPOS; SANCHES, PRISCILA DE LIMA; DE PIANO, ALINE; CARNIER, JUNE; DA SILVA, PATRICIA LEAO; GROTTI CLEMENTE, ANA P.; DE CASTRO FERREIRA VICENTE, SOFIA E.; OYAMA, LILA M.; et al. Homeostasis Model Assessment-Adiponectin: the role of different types of physical exercise in obese adolescents. JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS, v. 57, n. 6, p. 831-838, JUN 2017. (15/14309-9, 11/50414-0, 13/08522-6, 13/04136-4)

AGOSTINIS-SOBRINHO, CESAR; RAMIREZ-VELEZ, ROBINSON; NORKIENE, SIGUTE; DAMASO, ANA; GANEN, ALINE DE PIANO; LANDI MASQUIO, DEBORAH C.; RAUCKIEN-MICHAELSSON, ALONA; MOTA, JORGE; SANTOS, RUTE. Association of Adipocytokines and Inflammatory Biomarkers with Blood Pressure in Adolescents: A Longitudinal Analysis. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, v. 30, n. 12, p. 2296-2302, NOV 27 2020. (17/07372-1, 11/50414-0, 15/14309-9, 13/08522-6)

ANA CLAUDIA PELISSARI KRAVCHYCHYN; RAQUEL MUNHOZ DA SILVEIRA CAMPOS; YASMIN ALABY MARTINS FERREIRA; SOFIA EMANUELLE DE CASTRO FERREIRA VICENTE; FLÁVIA CAMPOS CORGOSINHO; LILA MISSAE OYAMA; DAVID THIVEL; LIAN TOCK; ANA RAIMUNDA DÂMASO. Higher increase degree of FGF21 post long-term interdisciplinary weight loss therapy preserves the free fat mass and rest metabolic rate in adolescents with obesity. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 64, n. 4, p. 479-482, 2020-04-06. (13/08522-6, 15/14309-9, 11/50414-0)

DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; DAMASO, ANA R.; LANDI MASQUIO, DEBORAH CRISTAINA; SENE-FIORESE, MARCELA; DUARTE, FERNANDA OLIVEIRA; AQUINO JUNIOR, ANTONIO EDUARDO; TOCK, LIAN; BAGNATO, VANDERLEI SALVADOR; PARIZOTTO, NIVALDO ANTONIO. Effects of Different Exercises Training associated with Phototherapy on Cardiometabolic Risk in Obese Women. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 49, n. 5, p. 1-pg., 2017-05-01. (15/14309-9, 13/19046-0, 13/08522-6)

DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; LANDI MASQUIO, DEBORAH CRISTINA; CORGOSINHO, FLAVIA CAMPOS; DE CARVALHO-FERREIRA, JOANA PEREIRA; NETTO, BARBARA DAL MOLIN; GROTTI CLEMENTE, ANA PAULA; TOCK, LIAN; TUFIK, SERGIO; DE MELLO, MARCO TULIO; DAMASO, ANA RAIMUNDA. Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 62, n. 3, p. 10-pg., 2018-05-01. (15/14309-9, 13/19046-0, 13/08522-6)

DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; LANDI MASQUIO, DEBORAH CRISTINA; CORGOSINHO, FLAVIA CAMPOS; DE CARVALHO-FERREIRA, JOANA PEREIRA; NETTO, BARBARA DAL MOLIN; GROTTI CLEMENTE, ANA PAULA; TOCK, LIAN; TUFIK, SERGIO; DE MELLO, MARCO TULIO; DAMASO, ANA RAIMUNDA. Relationship between adiponectin and leptin on osteocalcin in obese adolescents during weight loss therapy. ARCHIVES OF ENDOCRINOLOGY METABOLISM, v. 62, n. 3, p. 275-284, MAY-JUN 2018. (13/08522-6, 15/14309-9, 13/19046-0)

DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; LANDI MASQUIO, DEBORAH CRISTINA; CORGOSINHO, FLAVIA CAMPOS; CARANTI, DANIELLE ARISA; GANEN, ALINE DE PIANO; TOCK, LIAN; OYAMA, LILA MISSAE; DAMASO, ANA RAIMUNDA. Effects of magnitude of visceral adipose tissue reduction: Impact on insulin resistance, hyperleptinemia and cardiometabolic risk in adolescents with obesity after long-term weight-loss therapy. Diabetes & Vascular Disease Research, v. 16, n. 2, SI, p. 196-206, MAR 2019. (15/14309-9, 11/50414-0, 13/08522-6, 17/07372-1)

AGOSTINIS-SOBRINHO, CESAR; DE CASTRO FERREIRA VICENTE, SOFIA EMANUELLE; KIEVISIENE, JUSTINA; LOPES, LUIS; DAMASO, ANA RAIMUNDA; NORKIENE, SIGUTE; ROSARIO, RAFAELA; DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; RAMIREZ-VELEZ, ROBINSON; MOTA, JORGE; et al. High levels of adiponectin attenuate the detrimental association of adiposity with insulin resistance in adolescents. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, v. 30, n. 5, p. 822-828, MAY 7 2020. (17/07372-1, 15/14309-9, 13/08522-6, 11/50414-0)

DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; MOREIRA, CARLOS E.; DA SILVA, PATRICIA LEAO; LANDI MASQUIO, DEBORAH C.; CORGOSINHO, FLAVIA CAMPOS; PELISSARI KRAVCHYCHYN, ANA C.; DE CASTRO FERREIRA VICENTE, SOFIA E.; TOCK, LIAN; TUFIK, SERGIO; DE MELLO, MARCO T.; et al. The effect of aerobic plus resistance training associated with a long-term interdisciplinary weight loss program on visceral fat and isokinetic parameters in adolescents with obesity. JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS, v. 60, n. 6, p. 855-863, JUN 2020. (11/50414-0, 17/07372-1, 15/14309-9, 13/08522-6)

DAMASO, A. R.; VICENTE, S. E. C. F.; CORGOSINHO, F. C.; CAMPOS, R. M. S.; GANEN, A. P.; MASQUIO, D. C. L.; KRAVCHYCHYN, A. C. P.; TOCK, L.; MELLO, M. T.; OYAMA, L. M.; et al. THE ROLE OF ADIPONECTINEMIA ON METABOLIC AND INFLAMMATORY PROFILE OF OBESE ADOLESCENTS WITH NAFLD: EFFECTS OF LONG-TERM INTERDISCIPLINARY THERAPY. ACTA PAEDIATRICA, v. 106, p. 2-pg., 2017-11-01. (13/08522-6)

DA SILVEIRA CAMPOS, RAQUEL MUNHOZ; LANDI MASQUIO, DEBORAH CRISTINA; CORGOSINHO, FLAVIA CAMPOS; CARANTI, DANIELLE ARISA; GANEN, ALINE DE PIANO; TOCK, LIAN; OYAMA, LILA MISSAE; DAMASO, ANA RAIMUNDA. Effects of magnitude of visceral adipose tissue reduction: Impact on insulin resistance, hyperleptinemia and cardiometabolic risk in adolescents with obesity after long-term weight-loss therapy. Diabetes & Vascular Disease Research, v. 16, n. 2, p. 11-pg., 2019-03-01. (15/14309-9, 17/07372-1, 13/08522-6, 11/50414-0)

KRAVCHYCHYN, A. C. P.; CAMPOS, R. M. S.; DAL, MOLIN NETTO B.; FERREIRA, Y. A.; ABREU, J. D.; OYAMA, L. M.; GANEN, A. P.; CARANTI, D. A.; THIVEL, D.; TOCK, L.; et al. The impact of sugar-sweetened beverage and ultra-processed foods intake on leptin/adiponectin ratio in adolescents with obesity. ANNALS OF NUTRITION AND METABOLISM, v. 79, n. 1, p. 1-pg., 2023-02-01. (15/14309-9, 13/08522-6, 11/50414-0)