Nanocomposite biomaterials based on thermoresponsive HIDROGELS

• Grant number: 15/13958-3
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2015
• End date: August 31, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Emerson Rodrigues de Camargo
• Grantee: Emerson Rodrigues de Camargo
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated researchers: Luiz Fernando Gorup

Abstract

The treatment of many degenerative diseases or trauma injuries can be overcome using biomaterials, such as injectable hydrogels that are applicable for noninvasive surgery and exhibit potential action in the regeneration and repair of living tissues. The poly (N-vinylcaprolactam) (PNVCL) combined with poly (vinyl alcohol) (PVA) forms a biocompatible thermosensitive hydrogel with lower critical solution temperature (LCST) near to the human body temperature. This transition occurs due the change from a hydrophilic soluble state at lower temperature to a hydrophobic agglomerate state when it is heated. In this project, we will prepare a new class of nanocomposite hydrogels combining PNVCL/PVA synthesized by radical copolymerization with mesoporous silica nanofibers obtained by the Stöber method to improve their mechanical properties, and ytterbium trifluoride nanoparticles synthesized by hydrothermal processing to obtain radiopaque materials. Besides ensuring the biocompatibility of these nanocomposites are their use as scaffolds for tissue engineering, we expect to understand the influence of nanoparticles in the LCST and what factors affect the stability of the nanoparticles during the transition between the hydrophilic / hydrophobic phase (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ANDRESSA MAYUMI KUBO; LUIZ FERNANDO GORUP; LUCIANA SILVA AMARAL; EDSON RODRIGUES-FILHO; EMERSON RODRIGUES DE CAMARGO. Heterogeneous Microtubules of Self-assembled Silver and Gold Nanoparticles Using Alive Biotemplates. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 21, n. 4, 2018-05-28. (15/13958-3, 13/07296-2)

KUBO, ANDRESSA M.; GORUP, LUIZ F.; AMARAL, LUCIANA S.; FILHO, EDSON R.; CAMARGO, EMERSON R.. Kinetic Control of Microtubule Morphology Obtained by Assembling Gold Nanoparticles on Living Fungal Biotemplates. BIOCONJUGATE CHEMISTRY, v. 27, n. 10, p. 2337-2345, OCT 2016. (15/13958-3, 13/07296-2)

KUBO, ANDRESSA M.; GORUP, LUIZ F.; TOFFANO, LEONARDO; AMARAL, LUCIANA S.; RODRIGUES-FILHO, EDSON; MOHAN, HAIDER; AROCA, RICARDO; CAMARGO, EMERSON R.. Nanostructured Assemblies of Gold and Silver Nanoparticles for Plasmon Enhanced Spectroscopy Using Living Biotemplates. COLLOIDS AND INTERFACES, v. 1, n. 1, DEC 2017. (15/13958-3, 13/07296-2)

RIBEIRO, LUCAS S.; NOGUEIRA, ANDRE E.; AQUINO, JOSE M.; CAMARGO, EMERSON R.. A new strategy to obtain nano-scale particles of lithium titanate (Li4Ti5O12) by the oxidant peroxo method (OPM). CERAMICS INTERNATIONAL, v. 45, n. 18, p. 7-pg., 2019-12-15. (16/14667-5, 15/13958-3, 14/25616-7, 13/07296-2, 18/12871-0, 14/09014-7)

RIBEIRO, LUCAS S.; NOGUEIRA, ANDRE E.; AQUINO, JOSE M.; CAMARGO, EMERSON R.. A new strategy to obtain nano-scale particles of lithium titanate (Li4Ti5O12) by the oxidant peroxo method (OPM). CERAMICS INTERNATIONAL, v. 45, n. 18, A, p. 23917-23923, DEC 15 2019. (16/14667-5, 13/07296-2, 18/12871-0, 14/25616-7, 14/09014-7, 15/13958-3)

SALA, RENATA L.; VENANCIO, TIAGO; CAMARGO, EMERSON R.. Probing the Structural Dynamics of the Coil-Globule Transition of Thermosensitive Nanocomposite Hydrogels. Langmuir, v. 37, n. 4, p. 1531-1541, FEB 2 2021. (15/13958-3, 13/07296-2, 13/25663-2)

SALA, RENATA L.; GONCALVES, RICARDO H.; CAMARGO, EMERSON R.; LEITE, EDSON R.. Thermosensitive poly(N-vinylcaprolactam) as a transmission light regulator in smart windows. SOLAR ENERGY MATERIALS AND SOLAR CELLS, v. 186, p. 266-272, NOV 2018. (13/25663-2, 13/07296-2, 15/13958-3)

DE SOUZA NETO, FRANCISCO NUNES; SALA, RENATA LANG; FERNANDES, RENAN APARECIDO; OLIVEIRA XAVIER, TATIELIH PARDIM; CRUZ, SANDRA ANDREA; PARANHOS, CAIO MARCIO; MONTEIRO, DOUGLAS ROBERTO; BARBOSA, DEBORA BARROS; BOTAZZO DELBEM, ALBERTO CARLOS; DE CAMARGO, EMERSON RODRIGUES. Effect of synthetic colloidal nanoparticles in acrylic resin of dental use. EUROPEAN POLYMER JOURNAL, v. 112, p. 531-538, MAR 2019. (15/13958-3, 12/07067-0, 12/17880-0)