Bacterial cellulose functionalized with RGD peptides in tissue regeneration process

• Grant number: 15/17183-6
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2015
• End date: February 28, 2018
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: Reinaldo Marchetto
• Grantee: Reinaldo Marchetto
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• City of the host institution: Araraquara
• Associated researchers: Aderson Zottis ; Edson Crusca Junior

Abstract

The use of bacterial cellulose has a wide variety of applications due to their physical and chemical properties that give it excellent versatility. In medicine, their multifunctionality include temporary replacement of epithelial tissue in burns cases, ulcers, lesions or grafts, such as artificial blood vessels, as biologic curative for antibiotics and other drugs delivery and acting as a physical barrier to pathogens infections, in bone regeneration, among other applications.The tissue repair of the skin may be complicated by a number of factors, such as nutritional deficiency, diabetes, smoking, extent and location of injury or others cases in which the use of biomaterials that act as supports or substitutes that assist to accelerate the repair and healing processes, is a necessity.The RGD peptide sequence is found in many proteins of extracellular matrix (ECM), and is widely used to promote cell adhesion mediated by integrins in biomaterials due their wide distribution in the body and its ability to act in various cell adhesion receptors.Thus, this work is to develop a high-quality biomaterial by functionalization of bacterial cellulose with peptides containing the RGD sequence, to study its capacity to stimulate the adhesion and proliferation of fibroblasts, in order that it can be used in skin tissue regeneration. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PECORARO SANCHES, BEATRIZ CRISTINA; ROCHA, CAMILA AGUIAR; MARTIN BEDOYA, JOSE GREGORIO; DA SILVA, VINICIUS LUIZ; DA SILVA, PATRICIA BENTO; FUSCO-ALMEIDA, ANA MARISA; CHORILLI, MARLUS; CONTIERO, JONAS; CRUSCA, EDSON; MARCHETTO, REINALDO. Rhamnolipid-Based Liposomes as Promising Nano-Carriers for Enhancing the Antibacterial Activity of Peptides Derived from Bacterial Toxin-Antitoxin Systems. INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 16, p. 925-939, 2021. (15/17183-6)