Analysis of gene expression and phenotipic characteristics of avian pathogenic Escherichia coli strains(APEC) mutants for lysin descarboxilase operon (LDC-)

• Grant number: 15/03860-6
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2015
• End date: October 31, 2017
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
• Principal Investigator: Wanderley Dias da Silveira
• Grantee: Wanderley Dias da Silveira
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Janaína Luisa Leite Garbim ; Renato Pariz Maluta ; Thaís Cabrera Galvão Rojas

Abstract

Avian pathogenic Escherichia coli strains (APEC) are considered to be either primary or secondary infectious agents causing localized or systemic diseases in birds. Although many virulence genes in APEC strains, such as adhesions, secretion systems, iron biding systems, etc., were already described many other genes could play a role in the infectious process of this type of strain. The operon CAD (lysine descarboxilase) was shown to influence the virulence in Shigella and Escherichia coli strains of human origin. In this work we are going to study if the pathogenicity, the expression of virulence-associated genes and phenotypic characteristics of lysine descarboxilase negative APEC strains (LDC-), belonging to our bacterial collection, are influenced by the lack of this operon. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VERMA, RENU; GALVAO ROJAS, THAIS CABRERA; MALUTA, RENATO PARIZ; LEITE, JANAINA LUISA; NAKAZATO, GERSON; DE SILVEIRA, WANDERLEY DIAS. Role of hypothetical protein YicS in the pathogenicity of Avian Pathogenic Escherichia coli in vivo and in vitro. MICROBIOLOGICAL RESEARCH, v. 214, p. 28-36, 2018. (12/23289-3, 12/09655-7, 12/05073-3, 15/03860-6, 13/09167-5, 14/04860-7)