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Surface modification of graphene oxide with a dendrimer: A study of hybrid nanostructured materials for chemical and biological applications


In this project, we intend to modifying graphene oxide with a Polypropyleniimine tetraamine dendrimer (DAB-AM-4) by a chemical process, and explore its chemical and biological properties. The specific objectives of this project can be summarized in three steps. In a first step, it is desired to prepare and characterize by different techniques such as Ramam spectroscopy, Infrared spectroscopy (FTIR), UV-Visible (UV-Vis), X-ray Diffraction (XRD), Nuclear Magnetic Resonance (NMR), Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM), the product obtained of by reaction of graphene oxide with the dendrimer. In a second step, we intend to make a systematic study on the electrochemical properties of these materials, after the formation of a metal complex with potassium hexacianoferrate(III) (OGDH), employing cyclic voltammetry using solid electrode or graphite paste electrode containg OGDH as working electrode. After optimization of the electroanalytical system is intended to test these composites as sensors for the determination of species of the biological and environmental interest, mainly employing different electrochemical techniques such as square wave voltammetry, differential pulse voltammetry and chronoamperometry.The third step is to investigate the effect of association of cannabidiol and the graphene oxide modified with the dendrimer (OGD) in recovering the facilitatory effects of damage to the substantia nigra pars reticulata (SNpr) on epiletic seizures as well as define the pharmacological mechanisms of a possible antiepileptic effect of cannabidiol microinjected into the substantia nigra not only determining its course of action, but also an important place of therapeutic effect (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS SANTOS, VANESSA SOLFA; MARALDI, VITOR ALEXANDRE; BONFIM, KELY SILVEIRA; SOUZA, TAMIRES ROCHA; RIZZATO NAKAMURA, ANA PAULA; MAGOSSI, MAIARA DE SOUZA; MAGOSSI, MARIANA DE SOUZA; FERNANDES, DANIELA SILVESTRINI; DO CARMO, DEVANEY RIBEIRO. Voltammetric Behavior of Zinc Hexacyanoferrate (III) Nanoparticles and Their Application in the Detection of N-Acetylcysteine. International Journal of Electrochemical Science, v. 12, n. 8, p. 7142-7153, . (15/20397-8)
FERNANDES, DANIELA SILVESTRINI; BONFIM, KELY SILVEIRA; DO CARMO, DEVANEY RIBEIRO. Silver Hexacyanoferrate (III) on a Hybrid Graphene Oxide/PAMAM Dendrimer Surface and Application as an Electrocatalyst in the Detection of Isoniazid. Electroanalysis, v. 30, n. 6, p. 1107-1116, . (15/20397-8)
SOUZA, TAMIRES ROCHA; DE SA, ACELINO CARDOSO; DO CARMO, DEVANEY RIBEIRO. An investigation of the mixed water/formamide solvent on the synthesis of cadmium nitroprusside particles and its behavior in the electrochemical sensing of isoniazid. JOURNAL OF NANOPARTICLE RESEARCH, v. 23, n. 2, . (15/20397-8)
RIZZATO NAKAMURA, ANA PAULA; FERNANDES, DANIELA SILVESTRINI; VIEIRA, EDUARDO GUIMARAES; DIAS FILHO, NEWTON LUIS; DO CARMO, DEVANEY RIBEIRO. Voltammetric Detection of Nitrite Throught a Chemically Modified (5-Amino-1,3,4-Thiadiazolyl-2-Thiol) Propyl Silica Gel. SILICON, v. 13, n. 1, p. 221-229, . (15/20397-8)
MARALDI, VITOR ALEXANDRE; DO CARMO, DEVANEY RIBEIRO. Modification of the graphene oxide surface with copper pentacyanonitrosylferrate nanoparticles for electro-oxidation of hydrazine. CARBON LETTERS, v. 31, n. 4, p. 795-807, . (15/20397-8)
RIBEIRO, BEATRIZ F. M.; SOUZA, MARCELO M.; FERNANDES, DANIELA S.; DO CARMO, DEVANEY R.; MACHADO-SANTELLI, GLAUCIA M.. Graphene oxide-based nanomaterial interaction with human breast cancer cells. Journal of Biomedical Materials Research Part A, v. 108, n. 4, . (18/22882-9, 17/16893-5, 15/20397-8)
FRANCO, FERNANDA DOS SANTOS; PEIXOTO, MURILO SANTOS; BARONI, ABNER SANTOS; FELIPE, ALEXSANDRO DOS SANTOS; PEREIRA BARBOSA, PRISCILA FERNANDA; MARALDI, VITOR ALEXANDRE; LIMA FREITAS, REBECA MOREIRA; VICENTE DA SILVA, STEFANI FERNANDA; ALVES, VANESSA PETRONILIA; COUTO MORAES, ALVARO ADRIANO; et al. Voltammetric Behaviour of an Electroactive of Zn2+ - octa(aminopropyl)silsesquioxane nanocoposite : An Application to 4-Chlorophenol Detection in Tap Water. International Journal of Electrochemical Science, v. 17, n. 5, p. 16-pg., . (15/20397-8)

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