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Study of hypoxia mechanism and effect of adipose tissue- derived stem cell in the progression of kidney disease in SHR rats induced to metabolic syndrome

Grant number: 15/22318-8
Support type:Regular Research Grants
Duration: March 01, 2016 - August 31, 2018
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Miguel Cendoroglo Neto
Grantee:Miguel Cendoroglo Neto
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Assoc. researchers:Beata Marie Redublo Quinto ; Marcelo Costa Batista ; Maria Aparecida Dalboni ; Mário Luís Ribeiro Cesaretti ; Renata Nakamichi ; Vivian Regina Tristão


Currently adipose tissue has become the subject of great interest in the scientific community. It is considered an organ of endocrine and paracrine action that synthesizes several proteins implicated in the pathophysiology of obesity and Metabolic Syndrome, as well as an important source of stem cells, which have the capacity to proliferate and differentiate into many cell types including adipocytes, fibroblasts, macrophages, endothelial and mesenchymal cells. Recent studies have been conducted with the aim of using stem cells from adipose tissue in the treatment and prevention of renal disease progression, insulin resistance and cardiovascular disease. In fact, evidence point that the transplantation of stem cells in rat with ischemic heart disease resulted in increased capillary density in the infarct size, suggesting that these cells have the ability to differentiate into cardimyocyte and promote neovascularization. Additionally, studies suggest that stem cells derived from adipose tissue has not only the ability to differentiate into other cell types but are also able to participate in the reduction of inflammatory proteins in mice with renal ischemia .Based on knowledge of the ownership of multipotent stem cells arising from adipose tissue and their ability to differentiate into various cell types, being widely studied in the prevention and treatment of various diseases such as renal dysfunction, this study aims to use these cells in the treatment of Metabolic Syndrome, a set of metabolic and hemodynamic abnormalities, which is associated with increased risk of renal injury. (AU)