Protein quality control in dysfunctional/atrophic skeletal muscle: role of b2-adrenoceptor

• Grant number: 15/20783-5
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2016
• End date: March 31, 2018
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Julio Cesar Batista Ferreira
• Grantee: Julio Cesar Batista Ferreira
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Marcelo Alves da Silva Mori
• Associated research grant(s): 15/50429-9 - Protein quality control in dysfunctional/atrophic skeletal muscle: roke of B2 adrenoceptor, AP.R SPRINT

Abstract

The cellular protein quality control (PQC) machinery detects repairs and disposes cytotoxic proteins through different proteolytic systems (i.e. ubiquitin-proteasome system and autophagy). We recently demonstrated that improving PQC protects against cardiac diseases. Here, we are going to characterize the PQC profile as well as the benefits of sustained ²2-adrenoceptor activation, a positive PQC modulator, during skeletal muscle degeneration in a rat model of sciatic nerve constriction (SNC). (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KIYUNA, LIGIA AKEMI; PRESTES E ALBUQUERQUE, RUDA; CHEN, CHE-HONG; MOCHLY-ROSEN, DARIA; BATISTA FERREIRA, JULIO CESAR. Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities. Free Radical Biology and Medicine, v. 129, p. 155-168, DEC 2018. (17/16694-2, 17/14426-0, 16/00900-0, 15/22814-5, 15/20783-5, 12/05765-2, 13/07937-8)

CAMPOS, JULIANE C.; BAEHR, LESLIE M.; GOMES, KATIA M. S.; BECHARA, LUIZ R. G.; VOLTARELLI, VANESSA A.; BOZI, LUIZ H. M.; RIBEIRO, MARCIO A. C.; FERREIRA, NIKOLAS D.; MOREIRA, JOSE B. N.; BRUM, PATRICIA C.; et al. Exercise prevents impaired autophagy and proteostasis in a model of neurogenic myopathy. SCIENTIFIC REPORTS, v. 8, AUG 7 2018. (12/14416-1, 16/01633-5, 15/22814-5, 15/20783-5)

CAMPOS, JULIANE C.; BOZI, LUIZ H. M.; BECHARA, LUIZ R. G.; LIMA, VANESSA M.; FERREIRA, JULIO C. B.. Mitochondrial Quality Control in Cardiac Diseases. FRONTIERS IN PHYSIOLOGY, v. 7, OCT 21 2016. (12/19379-7, 12/14416-1, 15/20783-5, 12/05765-2, 16/01633-5)

FERREIRA, JULIO C. B.; CAMPOS, JULIANE C.; QVIT, NIR; QI, XIN; BOZI, LUIZ H. M.; BECHARA, LUIZ R. G.; LIMA, VANESSA M.; QUELICONI, BRUNO B.; DISATNIK, MARIE-HELENE; DOURADO, PAULO M. M.; et al. A selective inhibitor of mitofusin 1-beta IIPKC association improves heart failure outcome in rats. NATURE COMMUNICATIONS, v. 10, JAN 18 2019. (10/00028-4, 15/22814-5, 17/16694-2, 17/11142-1, 12/05765-2, 10/51906-1, 17/16540-5, 09/12349-2, 16/01633-5, 16/09611-0, 15/20783-5)

UETA, CINTIA BAGNE; CAMPOS, JULIANE CRUZ; PRESTES E ALBUQUERQUE, RUDA; LIMA, VANESSA MORAIS; DISATNIK, MARIE-HELENE; SANCHEZ, ANGELICA BIANCHINI; CHEN, CHE-HONG; GENNARI DE MEDEIROS, MARISA HELENA; YANG, WENJIN; MOCHLY-ROSEN, DARIA; et al. Cardioprotection induced by a brief exposure to acetaldehyde: role of aldehyde dehydrogenase 2. Cardiovascular Research, v. 114, n. 7, p. 1006-1015, JUN 1 2018. (12/05765-2, 13/07937-8, 15/20783-5, 13/11315-2)

CAMPOS, JULIANE C.; QUELICONI, BRUNO B.; BOZI, LUIZ H. M.; BECHARA, LUIZ R. G.; DOURADO, PAULO M. M.; ANDRES, ALLEN M.; JANNIG, PAULO R.; GOMES, KATIA M. S.; ZAMBELLI, VANESSA O.; ROCHA-RESENDE, CIBELE; et al. Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure. AUTOPHAGY, v. 13, n. 8, p. 1304-1317, 2017. (10/51906-1, 10/00028-4, 09/12349-2, 15/20783-5, 12/05765-2, 16/01633-5)

UETA, CINTIA B.; GOMES, KATIA S.; RIBEIRO, MARCIO A.; MOCHLY-ROSEN, DANIA; FERREIRA, JULIO C. B.. Disruption of mitochondrial quality control in peripheral artery disease: New therapeutic opportunities. PHARMACOLOGICAL RESEARCH, v. 115, p. 96-106, JAN 2017. (15/01759-6, 13/24321-0, 15/20783-5, 12/05765-2, 14/15187-1)

FERREIRA, JULIO C. B.; MORI, MARCELO A.; GROSS, ERIC R.. Mitochondrial Bioenergetics and Quality Control Mechanisms in Health and Disease. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2019, p. 3-pg., 2019-01-20. (15/20783-5, 17/07975-8, 17/01184-9, 12/05765-2, 18/18627-3, 17/16694-2)