The role of the Human Endogenous Retrovirus Family W (HERV-W) activity in the pathogenesis of multiple sclerosis investigated by transcriptome analysis of patients affected

• Grant number: 15/05958-3
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2016
• End date: March 31, 2018
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Camila Malta Romano
• Grantee: Camila Malta Romano
• Host Institution: Instituto de Medicina Tropical de São Paulo (IMT). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Augusto Cesar Penalva de Oliveira ; Emmanuel Dias-Neto ; Guilherme Sciascia do Olival ; Israel Tojal da Silva

Abstract

Multiple sclerosis (MS) is a disease of unknown etiology, difficult to treat, extremely complex and affecting more than 2.5 million people worldwide. It has an inflammatory stage and is characterized by the progressive and degenerative character. Endogenous retroviruses (ERVs) family W (HERV-W / MSRV - multiple sclerosis associated retrovirus) are super expressed in patients with MS, where it can be found mRNA in the blood and presence of the env protein in the lesions. Also, the expression of these elements inhibits the differentiation of oligodendrocyte precursor cells, directly blocking the remyelination process. Despite the evident involvement of MSRV with MS, it is still unclear the causes and consequences of this relationship, what elements are expressed and if the repertoire of active proviruses differs according to the nature of the disease. Currently, a new treatment for MS based on monoclonal antibodies directed to env protein / HERV-W is being developed, and a better understanding of the activity of HERVs in such patients now becomes essential. The aim of this study is to sequence the transcriptome of patients with MS in (i) conditions of exacerbation (relapses) and (ii) in remitting period, with emphasis on the analysis of the HERV-W family activity. The transcriptome of healthy individuals will also be held for comparison. We hope that data generated in this study can increase the understanding of the relationship between HERV-W and MS. Crucially, it is also our objective to generate enough data of affected individuals that allows analysis of other genes possibly involved in the pathogenesis of the disease. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RODRIGUES, LUCAS S.; DA SILVA NALI, LUIZ H.; LEAL, CIBELE O. D.; SABINO, ESTER C.; LACERDA, ELIANA M.; KINGDON, CAROLINE C.; NACUL, LUIS; ROMANO, CAMILA M.. HERV-K and HERV-W transcriptional activity in myalgic encephalomyelitis/chronic fatigue syndrome. AUTOIMMUNITY HIGHLIGHTS, v. 10, n. 1, DEC 2019. (15/05958-3)

RANGEL, SARA COELHO; DA SILVA, MICHELLY DAMASCENO; DA SILVA, AMANDA LOPES; DOS SANTOS, JULIANA DE MELO BATISTA; NEVES, LUCAS MELO; PEDROSA, ANA; RODRIGUES, FERNANDA MONTEIRO; TRETTEL, CAIO DOS SANTOS; FURTADO, GUILHERME EUSTAQUIO; DE BARROS, MARCELO PAES; et al. Human endogenous retroviruses and the inflammatory response: A vicious circle associated with health and illness. FRONTIERS IN IMMUNOLOGY, v. 13, p. 14-pg., 2022-11-23. (15/05958-3, 13/24223-9)

NALI, LUIZ H.; OLIVAL, GUILHERME S.; SOUSA, FRANCIELLE T. G.; DE OLIVEIRA, ANA CAROLINA S.; MONTENEGRO, HORACIO; DA SILVA, ISRAEL T.; DIAS-NETO, EMAMNUEL; NAYA, HUGO; SPANGENBERG, LUCIA; PENALVA-DE-OLIVEIRA, AUGUSTO C.; et al. Whole transcriptome analysis of multiple Sclerosis patients reveals active inflammatory profile in relapsing patients and downregulation of neurological repair pathways in secondary progressive cases. MULTIPLE SCLEROSIS AND RELATED DISORDERS, v. 44, SEP 2020. (13/24223-9, 15/05958-3)

REZENDE, HELDER RICAS; ROMANO, CAMILA MALTA; CLARO, INGRA MORALES; CALEIRO, GIOVANA SANTOS; SABINO, ESTER CERDEIRA; FELIX, ALVINA CLARA; BISSOLI, JEFFERSON; HILL, SARAH; FARIA, NUNO RODRIGUES; CARDOSO DA SILVA, THERESA CRISTINA; et al. First report of Aedes albopictus infected by Dengue and Zika virus in a rural outbreak in Brazil. PLoS One, v. 15, n. 3, MAR 12 2020. (15/05958-3, 18/14389-0)

CALEIRO, GIOVANA S.; NUNES, CRISTINA F.; URBANO, PAULO R.; KIRCHGATTER, KARIN; DE ARAUJO, JANSEN; DURIGON, EDISON LUIZ; THOMAZELLI, LUCIANO M.; STEWART, BRITTANY M.; EDWARDS, DUSTIN C.; ROMANO, CAMILA M.. Detection of Reticuloendotheliosis Virus in Muscovy Ducks, Wild Turkeys, and Chickens in Brazil. JOURNAL OF WILDLIFE DISEASES, v. 56, n. 3, p. 631-635, JUL 2020. (15/05958-3)

NALI, L. H.; DA SILVA, I. T.; DO OLIVAL, G. S.; DIAS-NETO, E.; SILVA, D. F.; URBANO, P. R.; TILBERY, C. P.; PENALVA-DE-OLIVEIRA, A. C.; ROMANO, C. M.; GRP NEUROCIENCIAS-IIER. Profile of HERV-W expression in multiple sclerosis patients. MULTIPLE SCLEROSIS, v. 22, p. 2-pg., 2016-09-01. (15/05958-3, 13/24223-9)